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SELECTBIO Conferences Flow Chemistry Asia 2019

Andrew Mansfield's Biography

Andrew Mansfield, Flow Chemistry Leader, Syrris

After graduating with a degree in Applied Chemistry Andrew moved into the research sector working for a range of Pharmaceutical companies including Roche, Napp, Parke-Davis and Pfizer. From an early point in his career he began to specialize in new enabling chemical technologies and automation specializing in high throughput synthesis and purification and flow chemistry.

At Pfizer Andrew led the flow chemistry initiative working across research projects and process groups to integrate flow chemistry in Pfizer's workflow. During this time that Andrew undertook an industrial secondment in Prof. Steve Ley's group developing his knowledge in the flow field. After the Pfizer (Sandwich) site closed Andrew took his expertise and ran his own consultancy company developing batch to flow processes, training and working with flow chemistry apparatus manufactures to develop their technology and develop in-house applications. Andrew moved to Syrris in early 2015 first in a technical role to develop flow chemistry applications, moving into Product Management before taking the position as Head of Flow Chemistry Products expanding his role to cover Syrris’ complete flow chemistry portfolio.

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Exploiting Segmented Flow Chemistry In Modern Compound Library Synthesis

Thursday, 14 November 2019 at 11:30

Add to Calendar ▼2019-11-14 11:30:002019-11-14 12:30:00Europe/LondonExploiting Segmented Flow Chemistry In Modern Compound Library SynthesisFlow Chemistry Asia 2019 in Tokyo, JapanTokyo,

The pharmaceutical industry continues to go through changes both in its approach to drug discovery and in the way, it uses new enabling technologies. The constant demand to deliver new drugs to market is the driver to adopt new strategies to improve the speed through early discovery to production and to the point of care. One of the major challenges faced today in drug discovery programs is the increasing demand to deliver a continuous supply of active compounds, generally novel and structurally diverse, in increasing numbers and in shorter timelines.  The use of continuous flow technology in the chemical synthesis of libraries allows the exploration of novel reaction windows to deliver a wider chemical space and more compound diversity over traditional methods. The technique enables the rapid optimization of synthetic protocols, access to reactions that were formerly avoided because of scale or safety concerns, telescoped reactions avoiding purification between steps and ready-made scale-up strategies.  This presentation illustrates how flow chemistry technology has enabled the synthesis of a range of structurally diverse compounds across a range of chemistries with the benefits of automation and reaction control.

Add to Calendar ▼2019-11-14 00:00:002019-11-15 00:00:00Europe/LondonFlow Chemistry Asia 2019Flow Chemistry Asia 2019 in Tokyo, JapanTokyo,