| Conferences \ 3D-Models for Drug Testing: Organoids & Tissue Chips 2022 \ Agenda \ Jeffrey Borenstein |
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Using Organs-on-Chips for Screening Therapeutics for Pandemic Respiratory InfectionsWednesday, 14 September 2022 at 14:30  Add to Calendar ▼2022-09-14 14:30:002022-09-14 15:30:00Europe/LondonUsing Organs-on-Chips for Screening Therapeutics for Pandemic Respiratory Infections3D-Models for Drug Testing: Organoids and Tissue Chips 2022 in SeattleSeattleSELECTBIOenquiries@selectbiosciences.comOne of the most powerful applications of organs-on-chips is as a platform for generating human-relevant data in screening therapeutic candidates across various disease models. Here we present recent therapeutic screening results obtained using the high throughput human primary tissue culture platform PREDICT96-ALI (Air Liquid Interface) across pandemic respiratory infections including Influenza A Virus (IAV) and the coronaviruses hCoV-NL63, hCoV-OC43 and SARS-CoV-2. These platforms, seeded with human primary tracheobronchial epithelial cells obtained from commercial sources as well as directly from bronchoscopies performed on living donors, enable rapid screening across a range of conditions including infection levels, cell source, candidate compound and therapeutic dose. In the case of SARS-CoV-2, this represents a first demonstration of successful therapeutic screening in a high containment BSL-3 environment. Results from the airway platform correlate closely with clinical data, demonstrating a compelling opportunity for an organ-on-chip model to serve a critical role in evaluating potential candidates capable of efficaciously treating severe respiratory infections. |
Add to Calendar ▼2022-09-13 00:00:002022-09-14 00:00:00Europe/London3D-Models for Drug Testing: Organoids and Tissue Chips 20223D-Models for Drug Testing: Organoids and Tissue Chips 2022 in SeattleSeattleSELECTBIOenquiries@selectbiosciences.com
