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SELECTBIO Conferences 3D-Printing and Biofabrication 2020

Orit Shefi's Biography

Orit Shefi, Associate Professor, Head of Neuroengineering Laboratory, Faculty of Engineering and Institute of Nanotechnologies and Advanced Materials, Bar-Ilan University Israel

Orit Shefi is an Associate Professor in the Faculty of Engineering at Bar Ilan University, the head of Neuro-engineering laboratory. She is a member of the Bar Ilan Institute of Nanotechnologies and Advanced Materials. She received her Ph.D. degree in 2005 from the Department of Physics, Tel-Aviv University, Israel. During the years 2005-2008 she was a postdoctoral fellow at the University of California, San Diego. Her research focuses on nanotechnologies for neuronal engineering, 3D platforms for directed neuronal regeneration, magnetic manipulations of cells, and drug delivery tools. She is a member of several editorial boards and in 2015 she was elected as an Associate Editor of Frontiers in Neuroscience – Neural Nanotechnology.

Selected Publications:

Zilony N. et al., Prolonged Controlled Delivery of Nerve Growth Factor Using Porous Silicon Nanostructures, Journal of Controlled Release, 2016.

Antman-Passig M. and Shefi O. Remote magnetic orientation of 3D collagen hydrogels for directed neuronal regeneration, Nano Letters , 2016.

Alon N. et al., Magnetic micro-device for manipulating PC12 cells migration and organization, Lab on a Chip, 2015.

Marcus M., et al., NGF-conjugated iron oxide nanoparticles promote differentiation and outgrowth of PC12 cells, Nanoscale, 2015.

Orit Shefi Image

Magnetic Manipulations for Controlling 3D Neural Network Formation

Tuesday, 18 August 2020 at 11:15

Add to Calendar ▼2020-08-18 11:15:002020-08-18 12:15:00Europe/LondonMagnetic Manipulations for Controlling 3D Neural Network Formation3D-Printing and Biofabrication 2020 in Boston, USABoston,

The ability to manipulate and direct neuronal growth has great implications in neural tissue engineering for both neuronal repair and potential medical devices. I will present our recent studies of magnetic-based manipulations  for promoting cell regeneration, controlling the organization of their extracellular environment and for directing drug delivery to the nervous system. As physical mechanical forces play a key role in neuronal morphogenesis, we use magnetic nanoparticles (MNPs) as mediators to apply forces locally on neurons throughout their migration and organization. Following incubation, the MNPs accumulated in the cells, turning the cells sensitive to magnetic stimulation. Applying magnetic fields with controlled magnetic flux densities leads to pre-designed cellular movement and to organized networks. Growing neurons loaded with MNPs under magnetic fields has affected the pattern of dendritic trees.  Moreover, we use the MNPs as mediators for shaping the 3D extracellular environment of regenerating neurons and as a platform for drug delivery, using magnetic targeting strategy to enhance therapeutic in selected cell populations. We conjugate covalently growth factors to iron oxide nanoparticles and use controlled magnetic fields to deliver the complexes to target sites. Our methods shows a controllable delivery system of biomolecules, together with integral guidance cues, presenting an emerging magneto-chemical approach for neuronal engineering and therapeutics.

Add to Calendar ▼2020-08-17 00:00:002020-08-18 00:00:00Europe/London3D-Printing and Biofabrication 20203D-Printing and Biofabrication 2020 in Boston, USABoston,