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SELECTBIO Conferences Organ-on-a-Chip and 3D-Culture: Companies, Technologies and Approaches

Orit Shefi's Biography

Orit Shefi, Associate Professor, Head of Neuroengineering Laboratory, Faculty of Engineering and Institute of Nanotechnologies and Advanced Materials, Bar-Ilan University Israel

Orit Shefi is an Associate Professor in the Faculty of Engineering at Bar Ilan University, the head of Neuro-engineering laboratory. She is a member of the Bar Ilan Institute of Nanotechnologies and Advanced Materials. She received her Ph.D. degree in 2005 from the Department of Physics, Tel-Aviv University, Israel. During the years 2005-2008 she was a postdoctoral fellow at the University of California, San Diego. Her research focuses on nanotechnologies for neuronal engineering, 3D platforms for directed neuronal regeneration, magnetic manipulations of cells, and drug delivery tools. She is a member of several editorial boards and in 2015 she was elected as an Associate Editor of Frontiers in Neuroscience – Neural Nanotechnology.

Selected Publications:

Zilony N. et al., Prolonged Controlled Delivery of Nerve Growth Factor Using Porous Silicon Nanostructures, Journal of Controlled Release, 2016.

Antman-Passig M. and Shefi O. Remote magnetic orientation of 3D collagen hydrogels for directed neuronal regeneration, Nano Letters , 2016.

Alon N. et al., Magnetic micro-device for manipulating PC12 cells migration and organization, Lab on a Chip, 2015.

Marcus M., et al., NGF-conjugated iron oxide nanoparticles promote differentiation and outgrowth of PC12 cells, Nanoscale, 2015.

Orit Shefi Image

Nano-Based Platforms For Controlling Neuronal Organization and Growth

Tuesday, 11 July 2017 at 09:30

Add to Calendar ▼2017-07-11 09:30:002017-07-11 10:30:00Europe/LondonNano-Based Platforms For Controlling Neuronal Organization and

In this talk I will present our recent studies of 3D nanostructured platforms for promoting and directing neuronal growth and drug delivery. As physical mechanical forces and contact guidance play key roles in neuronal morphogenesis, we used magnetic nanoparticles (MNPs) as mediators to apply forces locally on neurons throughout their migration. Following incubation, MNPs accumulated in the cells, turning the cells sensitive to magnetic stimulation. Then, we applied magnetic fields with controlled magnetic flux densities at multiple scales of size and strength. Plating the cells atop a magnetic micropatterned device has led to an organized network of cell clusters. Next, we used the ability to control MNP movement to shape the extracellular environment of the cells. We mixed MNPs in collagen hydrogel and applied external magnetic field during the gelation period, aligning the MNPs and the collagen fibers. As neurons rely on physical topographical elements, neurons embedded within the aligned gel demonstrated polarized growth pattern. This platform is now examined as a novel method to direct neuronal growth and to bridge gaps efficiently post trauma. Our study presents an emerging magneto-chemical approach for promoting neuronal growth and repair.

Add to Calendar ▼2017-07-10 00:00:002017-07-11 00:00:00Europe/LondonOrgan-on-a-Chip and 3D-Culture: Companies, Technologies and