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SELECTBIO Conferences Organ-on-a-Chip, Tissue-on-a-Chip Europe 2018

Michael Moore's Biography

Michael Moore, Associate Professor of Biomedical Engineering; Co-founder and CSO, AxoSim Technologies, Tulane University

Michael J. Moore is an Associate Professor of Biomedical Engineering and director of the Neural Microengineering Laboratory at Tulane University, and he is co-founder and CSO of AxoSim Technologies. His research is focused on the development of advanced tissue models of the nervous system for studying axon guidance modeling neurological disorders. Prior to joining the faculty at Tulane, Dr. Moore received his BS in Biological Systems Engineering from the University of Nebraska (1999), and his PhD in biomedical engineering from the Mayo Clinic College of Medicine (2005), where he developed a biodegradable spinal cord implant. He then went on to conduct postdoctoral research in drug delivery for retinal neuroprotection with Robert Langer at MIT. Dr. Moore joined the Tulane Biomedical Engineering faculty in 2007, and in 2014, Dr. Moore co-founded AxoSim, a start-up company commercializing microphysiological models of the nervous system for drug development. He lives with his wife Lisa and their three children in New Orleans.

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Peripheral Nerve-on-a-Chip: Quantifying Myelination and Demyelination

Wednesday, 6 June 2018 at 11:00

Add to Calendar ▼2018-06-06 11:00:002018-06-06 12:00:00Europe/LondonPeripheral Nerve-on-a-Chip: Quantifying Myelination and DemyelinationOrgan-on-a-Chip, Tissue-on-a-Chip Europe 2018 in Rotterdam, The NetherlandsRotterdam, The

Development of microphysiological models of the peripheral nervous system have lagged that of other organ systems. This is perhaps partially because peripheral nerve disorders are rarely life-threatening, though they are frequently severely debilitating. The most effective organ-on-a-chip models are those that reflect relevant anatomical and physiological features, enabling comparisons with animal studies or clinical outcomes. In our model of rat myelinated peripheral nerve, we show that we can quantify key measurements using histology and nerve conduction, exactly the main quantitative endpoints used in preclinical or clinical studies to assess peripheral nerve degeneration. In particular, we show that nerve conduction velocity correlates with myelin formation, as measured by % myelinated axons and g-ratio. In like manner, induced demyelination leads to structural degeneration and functional deficits that may also be quantified using histology and nerve conduction. This model is unique in its ability to capture these specific metrics of peripheral nerve health. Ongoing challenges and implications for modeling demyelinating disorders will also be discussed.

Add to Calendar ▼2018-06-05 00:00:002018-06-06 00:00:00Europe/LondonOrgan-on-a-Chip, Tissue-on-a-Chip Europe 2018Organ-on-a-Chip, Tissue-on-a-Chip Europe 2018 in Rotterdam, The NetherlandsRotterdam, The