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SELECTBIO Conferences Biofabrication & Biomanufacturing Europe 2019

Dror Seliktar's Biography

Dror Seliktar, Associate Professor, Faculty of Biomedical Engineering, Technion-Israel Institute of Technology

Dr. Dror Seliktar is an associate professor on the Technion’s Faculty of Biomedical Engineering. His primary area of interest is in the field of tissue engineering and regenerative medicine with an emphasis on hydrogel biomaterials and biomechanics. His academic research focuses specifically on novel hydrogel biomaterials for tissue engineering, regulation of morphogenesis via physical properties in 3-D culture, and mechanobiology in tissue engineering. His applied research in tissue regeneration has led to the discovery of a new biomaterial, Gelrin™, which has been licensed to a company called Regentis Biomaterials Ltd., of which he is a founder. The technology transfer of the patented Gelrin biomaterial technology from the Technion into human clinical trials, which are currently underway in Europe and USA, has been an integral part of his tenure in the department. He has presented his scientific findings at numerous professional meeting and scientific conferences and has authored or co-authored over 120 publications. He has received several awards for his research and teaching accomplishments, including the prestigious Rita Levi-Montalcini Award. In addition, he was awarded a large-scale international cooperation grant from the Singapore government in the area of cardiac restoration therapies; he served as the founding director and lead PI of this multi-national collaborative endeavor.

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Microscopic Laser Photolithography for Designing In Situ Architectures in 3D Cell-Laden Hydrogels

Thursday, 20 June 2019 at 10:00

Add to Calendar ▼2019-06-20 10:00:002019-06-20 11:00:00Europe/LondonMicroscopic Laser Photolithography for Designing In Situ Architectures in 3D Cell-Laden HydrogelsBiofabrication and Biomanufacturing Europe 2019 in Rotterdam, The NetherlandsRotterdam, The

One of the key advantages in using light-sensitive hydrogel biomaterials is the ability to spatially structure cell scaffolds with three-dimensional mechanical cues that guide cellular morphogenesis. However, creating unique mechanical landscapes within these materials – with resident cells present – has proven difficult because of the high toxicity associated with the localized photochemical interactions. To overcome this challenge, we developed a new paradigm in micro-patterning using a reversible temperature-induced phase transition from liquid to solid vis-à-vis lower critical solubility temperature (LCST) in order to facilitate reduced transport kinetics of the polymer chains in solution, thus enabling mild microscopic photo-chemical crosslinking that is truly compatible with cell-laden 3D culture. Temperature responsive bioactive hydrogels were made from fibrinogen and Pluronic®F127 (FF127) that are physically crosslinked at physiologic temperatures and can be locally altered by mild in situ chemical cross-linking using microscopic photolithography, without compromising cellular viability. FF127 constructs made with rhodamine-labeled F127-Acrylate were used to pinpoint the patterned regions of chemical crosslinking in the physically crosslinked hydrogels, while particle tracking microrheology was used to study the local mechanical properties of these heterogeneous networks. Cellularized constructs where patterned to reveal a difference in morphogenesis between chemically crosslinked “stiffer” and physically crosslinked “softer” regions. Emphasizing the importance of mechanical heterogeneity in cellular morphogenesis, the results validate cutting-edge technology that can provide scientists with a robust set of tools for engineering cell and tissue growth in three dimensions.

Add to Calendar ▼2019-06-20 00:00:002019-06-21 00:00:00Europe/LondonBiofabrication and Biomanufacturing Europe 2019Biofabrication and Biomanufacturing Europe 2019 in Rotterdam, The NetherlandsRotterdam, The