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SELECTBIO Conferences Flow Chemistry Congress 2018

Amanda Evans's Biography

Amanda Evans, Assistant Professor, California State University Fullerton

Dr. Evans received her Ph.D. in organic synthesis from the University of Cambridge (Professor Steven Ley). She was subsequently appointed as a Teaching Fellow and Director of Studies in Chemistry at Murray Edwards College, University of Cambridge. She has been a Fulbright Scholar and a RSC JWT Fellowship recipient, in addition to appointment as a Visiting Professorship at the University of Nice – Sophia Antipolis, prior to accepting her current post. Dr. Evans recently joined California State University Fullerton as an Assistant Professor in Bio-Organic Chemistry. Her research group uses both batch and continuous processing/bioprocessing approaches for making molecules and her research interests are diverse as she has performed postdoctoral research in the fields of microfluidic synthesis, asymmetric prebiotic chemistry, DNA nanotechnology, and polymeric materials. She possesses an extensive background in the generation of chiral substrates and the use of synthetic techniques in combination with other cross-disciplinary methods to construct and characterize molecular or macromolecular compounds with useful material and/or biological properties for interdisciplinary applications. She is particularly interested in establishing more innovative, scalable and sustainable enabling methodologies for creating chiral molecules.

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Tunable Chiroptical Induction in Flow

Monday, 12 November 2018 at 13:30

Add to Calendar ▼2018-11-12 13:30:002018-11-12 14:30:00Europe/LondonTunable Chiroptical Induction in FlowFlow Chemistry Congress 2018 in Miami, FloridaMiami,

This talk will focus on the use of circularly polarized (cp), or “chiral”, light as a supramolecular chiroptical field for the induction of asymmetry in small molecule building blocks as a continuous photochemical process. Enantioselective chiral photolysis of small molecules has already been achieved under batch, solid-phase conditions:  using synchrotron-sourced cp light, asymmetric photolytic selectivities of up to 4.2% enantiomeric excess (e.e.) have been reported. The optimal wavelengths to use for chiroptical photochemical induction with cp light for any given molecular building block are determined from the CD and anisotropy spectra for each building block of interest. These spectra have been experimentally measured for a small library of building blocks in two different solvents (water, hexafluoroisopropanol) across a range of wavelengths (130-400 nm). A series of both batch and continuous photochemical processing experiments have been performed using synchrotron-sourced cp light as the sole source of chiroptical induction under a number of different conditions. A mechanism for asymmetry generation in these small molecule building blocks in solvent and methods for enhancing the initial selectivities observed will be discussed. Predictive approaches for describing the behavior of similar small molecules will also be presented.

Add to Calendar ▼2018-11-12 00:00:002018-11-13 00:00:00Europe/LondonFlow Chemistry Congress 2018Flow Chemistry Congress 2018 in Miami, FloridaMiami,