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SELECTBIO Conferences Organ-on-a-Chip and 3D-Culture: Companies, Technologies and Approaches

Joseph L Charest's Biography

Joseph L Charest, Program Manager, Charles Stark Draper Laboratory

Dr. Charest is a Program Manager for Draper’s Human Organ Systems where he directs efforts to build systems which recapitulate human organ function. The systems are in vitro models of human tissue which exhibit the function of native organs and can be used to screen effects of drugs and other therapies on those organs. His teams leverage micro/nano-fabrication, microfluidics, and advanced machining techniques to create systems to coax cells into forming functional tissue with the end result speeding development of therapies to better treat patients. Dr. Charest graduated from Georgia Tech with an MS and PhD in Mechanical Engineering and from Penn State Honors College with a BS in Mechanical Engineering and has worked at Bell Labs/Lucent Technologies, Sandia National Labs, and several startups/spinouts.

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Leveraging Microfabrication to Create Scalable Complex in vitro Models of Tissue

Monday, 10 July 2017 at 15:30

Add to Calendar ▼2017-07-10 15:30:002017-07-10 16:30:00Europe/LondonLeveraging Microfabrication to Create Scalable Complex in vitro Models of

We present a microfluidics-based model tissue which expresses active organ-specific function.  Controlled microfluidic fluid flow, cell-substrate topography, and cell-cell cues are used to create tissue which can be evaluated within the microfluidic architecture for barrier function and active transport function.  To achieve higher levels of throughput, the model can be replicated within a 96-well format while still maintaining the unique characteristic of controlled flow.  To improve data collection, integrated electrical traces measure trans-epithelial/endothelial electrical resistance (TEER) in near real-time and provide a means to create additional sensing capabilities in the future.  The microfluidic model demonstrates the ability to generate tissue in vitro with tissue-specific function, provides near real-time feedback on tissue barrier function, and can scale to relevant levels of throughput resulting in a screening tool for drug interaction with transport tissues.

Add to Calendar ▼2017-07-10 00:00:002017-07-11 00:00:00Europe/LondonOrgan-on-a-Chip and 3D-Culture: Companies, Technologies and