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SELECTBIO Conferences Lab-on-a-Chip and Microfluidics Europe 2020

Amy Shen's Biography



Amy Shen, Professor, Okinawa Institute of Science and Technology

Amy Shen is a professor in Micro/Bio/Nanofluidics Unit at Okinawa Institute of Science and Technology in Japan (https://groups.oist.jp/mbnu). She was a faculty member at Mechanical Engineering and Chemical Engineering at University of Washington before moving to Japan in 2014. Amy's research is focused on fluid manipulations at small length scales, with applications in micro/nanofluidics and biosensors. Some of her recent work include micro/nanofluidic based immunoassays, novel micromixing phenomena, and localized surface plasmon resonance (LSPR) sensors for lab-on-a-chip devices. Amy is an honor member of Phi Kappa Phi and Pi Tau Sigma. Amy received Ralph E. Powe Junior Faculty Enhancement Award in 2003 and the National Science Foundation's CAREER Award in 2007. Amy was also a Fulbright Scholar in 2013.

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Detection of Antibodies Against SARS-CoV-2 Spike Protein by Gold Nanospikes in an Optomicrofluidic Chip

Wednesday, 9 September 2020 at 09:00

Add to Calendar ▼2020-09-09 09:00:002020-09-09 10:00:00Europe/LondonDetection of Antibodies Against SARS-CoV-2 Spike Protein by Gold Nanospikes in an Optomicrofluidic ChipLab-on-a-Chip and Microfluidics Europe 2020 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com

The ongoing global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to active research in its associated diagnostics and medical treatments. While quantitative reverse transcription polymerase chain reaction (qRT--PCR) is the most reliable method to detect viral genes of SARS-CoV-2, serological tests for specific antiviral antibodies are also important as they identify false negative qRT--PCR responses, track how effectively the patient's immune system is fighting the infection, and are potentially helpful for plasma transfusion therapies. In this work, based on the principle of localized surface plasmon resonance (LSPR), we develop an optomicrofluidic sensing platform with gold nanospikes, fabricated by electrodeposition, to detect the presence and amount of antibodies specific to the SARS-CoV-2 spike protein in 1 uL of human plasma diluted in 1 mL of buffer solution, within ~30~min. The target antibody concentration can be correlated with the LSPR wavelength peak shift of gold nanospikes caused by the local refractive index change due to the antigen-antibody binding. This label-free microfluidic platform achieves a limit of detection of ~0.08~ng/mL (~0.5~pM), falling under the clinical relevant concentration range. We demonstrate that our opto-microfluidic platform offers a promising point-of-care testing tool to complement standard serological assays and make SARS-CoV-2 quantitative diagnostics easier, cheaper, and faster.


Add to Calendar ▼2020-09-09 00:00:002020-09-10 00:00:00Europe/LondonLab-on-a-Chip and Microfluidics Europe 2020Lab-on-a-Chip and Microfluidics Europe 2020 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com