| Conferences \ Organ-on-a-Chip World Congress & 3D-Culture 2016 \ Organs-on-Chips and 3D-Cultures: Technologies and Approaches \ Agenda \ Maria Carla Parrini |
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Reconstitution and Visualization of Tumors-on-Chip for Precision MedicineFriday, 8 July 2016 at 15:00  Add to Calendar ▼2016-07-08 15:00:002016-07-08 16:00:00Europe/LondonReconstitution and Visualization of Tumors-on-Chip for Precision MedicineSELECTBIOenquiries@selectbiosciences.comTumor microenvironments are ecosystems composed of a variety of cell types positioned in complex physicochemical contexts. We generated microfluidic devices in which highly-controlled cell co-cultures reconstituted a breast tumor ecosystem (Her2+ sub-type), containing cancer cells, cancer-associated fibroblasts, endothelial cells, and immune cells. We succeeded in recapitulating on these tumors-on-chip the immune-dependent systemic response to a drug used in clinic, the Trastuzumab monoclonal antibody (Herceptin®). This approach provides a novel experimental system to understand the complex effects of Trastuzumab on the tumor microenvironment and, very importantly, to investigate its resistance mechanisms. We are currently working toward the personalization of these tumors-on-chip by the introduction of patient-derived cells in the perspective of personalized diagnostic and precision medicine. |
Add to Calendar ▼2016-07-07 00:00:002016-07-08 00:00:00Europe/LondonOrgans-on-Chips and 3D-Cultures: Technologies and ApproachesSELECTBIOenquiries@selectbiosciences.com
