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SELECTBIO Conferences Organ-on-a-Chip, Tissue-on-a-Chip Europe 2018

Rhiannon David's Biography

Rhiannon David, Senior Scientist, AstraZeneca

Rhiannon is a Senior Scientist in the Genetic Toxicology group, part of the wider Discovery Safety team at AstraZeneca, Cambridge, UK. Rhiannon received her PhD in genetic toxicology from the University of Birmingham in 2009 and following this joined the Department of Medicine at Imperial College, London, where she spent 5 years as a postdoctoral scientist, undertaking research into the genotoxicity of mixtures of food-derived genotoxic carcinogens. During this time, Rhiannon developed an interest in novel techniques that would improve the in vivo relevance of in vitro assays, and investigated the use of organotypic 3D culture for genetic toxicology tests. In her current role, Rhiannon delivers genotoxicity safety assessment of potential new therapeutics across multiple therapy areas, and is involved in the development of microphysiological systems for safety assessment.

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Advancing Pre-Clinical Safety Assessment with Organs-on-Chips

Wednesday, 6 June 2018 at 09:00

Add to Calendar ▼2018-06-06 09:00:002018-06-06 10:00:00Europe/LondonAdvancing Pre-Clinical Safety Assessment with Organs-on-ChipsOrgan-on-a-Chip, Tissue-on-a-Chip Europe 2018 in Rotterdam, The NetherlandsRotterdam, The

Organs-on-chips (microphysiological systems (MPS)) aim to recapitulate the architecture, cell-cell interactions, and microenvironment of different tissues, which is more representative of their complex in vivo biology. Human-sourced MPS provide an opportunity to generate safety and efficacy data for drug development with improved clinical relevance over more traditional animal models. This presentation will outline the context of use of MPS at AstraZeneca and give examples of data generated from these systems, with a focus on the development of a bone marrow-on-a-chip to better predict clinically-observed toxicity.

Add to Calendar ▼2018-06-05 00:00:002018-06-06 00:00:00Europe/LondonOrgan-on-a-Chip, Tissue-on-a-Chip Europe 2018Organ-on-a-Chip, Tissue-on-a-Chip Europe 2018 in Rotterdam, The NetherlandsRotterdam, The