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SELECTBIO Conferences Lab-on-a-Chip and Microfluidics: Companies, Technologies and Commercialization

Anne Varenne's Biography

Anne Varenne, Professor, Chimie ParisTech, Unité de Technologies Chimiques et Biologiques pour la Santé

Dr. Anne Varenne is professor of analytical chemistry. Her expertise concern (i) Separation sciences, analytical methodology developments & technologies, (ii) Hyphenation of electrokinetic methodologies to detection techniques (fluorescence, mass spectrometry, electrochemistry), (iii) Characterization of nanoprobes, nanosupports, biological systems & specific noncovalent complexes for their interests in electrokinetic separation methods, diagnostics, imaging & therapy, and (iv) Design of miniaturised total analysis systems, microsystem functionalizations. She is president of the scientific cooperation program ECOS-Nord (French ministeries of foreign affairs and of higher education and investigation for academic and scientific cooperation). She was awarded with the “Prix l’Oréal” in 1995, and the “Prix de la division Chimie Analytique de la Société Française de Chimie” in 2004. She has a high expertise in project management, as team leader for different pluridisciplinary projects in the context of ANR, Chaire Areva, Labex IPGG, Fondation Pierre Gilles de Gennes (FPGG), Swiss National Science Foundation (SNSF), and international collaborations with foreign universities (Guanajuato University, Fudan University,…). She is author or co-author of more than 80 articles.

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Design of a Lab-on-a-Chip for the Quantitation of S-Nitrosothiols: From their Separation to their Decomposition and Electrochemical Detection

Wednesday, 28 September 2016 at 14:30

Add to Calendar ▼2016-09-28 14:30:002016-09-28 15:30:00Europe/LondonDesign of a Lab-on-a-Chip for the Quantitation of S-Nitrosothiols: From their Separation to their Decomposition and Electrochemical

NO is a diatomic free radical that has in biological fluids extremely short half-life (<1 s). The addition of NO to functional proteins is as important as phosphorylation in its consequences on cellular activities. In order to be transported and stocked in biological fluids, NO binds to peptides and proteins forming S-nitrosothiols (RSNOs). The variation of their proportion has been recognized in many diseases.  RSNO are sensitive to decomposition by light, heat, and metal ions. RSNOs can exchange the NO between one other by transnitrosation reaction. Recently we studied the separation of different RSNOs and their transnitrosation reaction using capillary electrophoresis with capacitively coupled contactless conductivity detection. Also, we developed a decomposition process of RSNO using copper to quantify RSNO by electrochemical techniques (ultra-micro electrodes). We are currently down scaling these approaches within microchip devices. This opens the way for an integrated lab-on-a-chip for S-nitrosothiols quantitation.

Add to Calendar ▼2016-09-26 00:00:002016-09-28 00:00:00Europe/LondonLab-on-a-Chip and Microfluidics: Companies, Technologies and