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SELECTBIO Conferences Organ-on-a-Chip and 3D-Culture: Companies, Technologies and Approaches

Katia Karalis's Biography

Katia Karalis, Executive Vice President of Research, Emulate, Inc.

Dr. Katia Karalis is the Vice President of Research at Emulate, Inc. Based on their Organs-on-Chips technology platform, the company is developing a new living human system that combines cell biology within micro-engineered environments - for researchers to accurately understand how different diseases, medicines, chemicals and foods will affect human health. Karalis’ career spans continents, academics and industry. Prior to joining Emulate she was an Assistant Professor of Pediatrics at Harvard Medical School as well as a Visiting Scholar at the Wyss Institute for Biologically Inspired Engineering at Harvard University. She is affiliated with the Division of Endocrinology of Children's Hospital, Harvard Medical School, and TU Dresden, Medical School, in Germany. As well she is a part of the Biomedical Research Foundation of the Academy of Athens, Greece. After her academic career training in basic Endocrinology at Cedars Sinai-UCLA and the NIH, she studied Clinical Molecular Genetics at Harvard Medical School. She joined the faculty of the Department of Medicine, Children’s Hospital Boston at Harvard Medical School. Karalis was recruited to set up the Developmental Biology Section of the Biomedical Research Foundation of the Academy of Athens (BRFAA). Karalis’ 30 years of faculty appointments, membership in medical societies and grant review activities has been at the cutting edge of Human Genetic Research, endocrine, liver and gastrointestinal studies. Her numerous honors and prizes include the Fogarty Fellowship (US Government), Fellow, Institute for Advancement of Sciences, Warwick University, UK and Honorary Affiliate TUM Dresden, FDR. Karalis received both her MD and PhD from University of Athens, Greece. Her Post-Doctoral training was in Endocrinology at NIH, Bethesda, MD and Children’s Hospital, Boston. As well her Clinical Molecular Genetics post-doctoral training was in the Harvard Medical School Genetics Training Program with her Clinical Cytogenetics Training at Brigham and Women’s Hospital, Boston. She has authored over 50 papers in peer-reviewed publications.

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Human Emulation System: an Organs-on-Chips Platform for Advancing Drug Discovery and Development

Monday, 10 July 2017 at 11:30

Add to Calendar ▼2017-07-10 11:30:002017-07-10 12:30:00Europe/LondonHuman Emulation System: an Organs-on-Chips Platform for Advancing Drug Discovery and

Micro-engineered Organs-on-Chips show physiological functions consistent with normal living human or animal cells in vivo. Each Organ-Chip is composed of a clear flexible polymer about the size of a AA battery that contains hollow channels lined by living human cells. The cells are cultured under continuous flow and mechanical forces thereby recreating key factors known to influence cell function in vivo.  Cells cultured  under continuously perfused, engineered 3D microenvironments go beyond conventional 3D in vitro models by recapitulating in vivo intercellular interactions, spatiotemporal gradients, vascular perfusion, and mechanical microenvironments. Integrating cells within Organs-on-Chips, enables the study of normal physiology and pathophysiology in an organ-specific context.  Cellular/molecular level resolution is enhanced and demonstrates key insights into the mechanisms of action of drug induced toxicity.   Numerous recent advances in applications of these systems are relevant in drug discovery/development for compound selection, and in de-risking mechanistic concerns using various organ systems. In this presentation we will highlight studies from collaborative efforts across our Human Emulation System with various academic and industry partners to demonstrate the utility of the system as a more predictive human-relevant alternative for efficacy and safety testing of new chemical entities in humans.

Add to Calendar ▼2017-07-10 00:00:002017-07-11 00:00:00Europe/LondonOrgan-on-a-Chip and 3D-Culture: Companies, Technologies and