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SELECTBIO Conferences Stem Cells in Drug Discovery & Toxicity Screening 2018

Robert Halliwell's Biography



Robert Halliwell, Professor of Neuroscience and Clinical Pharmacology, University of The Pacific

Robert F. Halliwell is Professor of Neuroscience and Clinical Pharmacology in the Schools of Pharmacy and Dentistry, University of the Pacific; he previously held a lectureship in Neuroscience at the University of Durham, England and a Research Fellowship at the University of California, Irvine. Dr Halliwell undertook graduate training at University College London and at Ninewells Hospital and Medical School, University of Dundee. His lab is conducting experiments to determine the functional properties of neurons derived from human stem cells; he has also published work in the history of medicine with a book on the history of the drug receptor concept.

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Evaluation of Human Stem Cell-derived Neurons for Neuropsychiatric Drug Discovery and Safety Testing

Friday, 5 October 2018 at 09:30

Add to Calendar ▼2018-10-05 09:30:002018-10-05 10:30:00Europe/LondonEvaluation of Human Stem Cell-derived Neurons for Neuropsychiatric Drug Discovery and Safety TestingStem Cells in Drug Discovery and Toxicity Screening 2018 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com

Studies in neuropharmacology and neurotoxicology have relied extensively on animal models that are inefficient, costly and of poor predictive validity; there are also ethical concerns about using large numbers of animals in biomedical research. Developments in stem cell science have provided new opportunities to generate human neurons from stem cells but characterization of these cells is still at an early stage.

Our lab is investigating several sources of adult (somatic) stem, induced pluripotent stem (iPS) and embryonic stem (ES) cells to differentiate into functional human neurons. We are using patch-clamp electrophysiology, immunocytochemistry and flow cytometry to determine the neuropharmacological and neurophysiological properties of neurons derived from iPS and somatic stem cells. In addition, we are addressing the potential value of these human stem cells in vitro to predict developmental neurotoxicity that can occur in vivo through exposure to environmental agents and therapeutic medicines, including anticonvulsant drugs.

Our results will illustrate the value of stem cell-derived neurons in the discovery and development of new neuropsychiatric medicines and in the evaluation of their safety.


Add to Calendar ▼2018-10-04 00:00:002018-10-05 00:00:00Europe/LondonStem Cells in Drug Discovery and Toxicity Screening 2018Stem Cells in Drug Discovery and Toxicity Screening 2018 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com