Neta Regev-Rudzki,
Assistant Professor, Department of Biomolecular Sciences,
Weizmann Institute of Science
Dr. Neta Regev-Rudzki completed a BSc in chemistry, an MSc in biochemistry, and a PhD in microbiology and cell biology (2010), all at the Hebrew University in Jerusalem. During her postdoctoral training at the Walter and Eliza Hall Institute of Medical Research (WEHI) in Melbourne, Australia, she became interested in parasitology and turned her attention to malaria. While working as a postdoctoral researcher, she discovered that malaria parasites, which live inside red blood cells, transfer episomal genes between them via exosome-like vesicles. Dr. Regev-Rudzki joined the faculty of the Department of Biomolecular Sciences at the Weizmann Institute of Science (Israel) in October 2014. Dr Regev-Rudzki’s lab is focused on studying modes of cell-cell communication developed by one of the most lethal human pathogens, malaria parasites.
Malaria Parasites use DNA-Harbouring Vesicles as a Mechanism to Activate Cytosolic Immune Sensors
Thursday, 28 September 2017 at 11:45
Add to Calendar ▼2017-09-28 11:45:002017-09-28 12:45:00Europe/LondonMalaria Parasites use DNA-Harbouring Vesicles as a Mechanism to Activate Cytosolic Immune SensorsExtracellular Vesicles 2017 in Cripps Court, Magdalene College, Cambridge, UKCripps Court, Magdalene College, Cambridge, UKSELECTBIOenquiries@selectbiosciences.com
Malaria, caused by Plasmodium falciparum (Pf), is a devastating parasitic disease affecting hundreds of millions of people worldwide. The parasite’s transmission cycle between humans and mosquitoes involves a remarkable series of morphological transformations and in each context the parasites face very hostile environment. Here we discovered that at specific stage post-invasion into their host red blood cells (RBCs), the parasites secrete DNA-harbouring vesicles. The vesicles are taken up by human monocytes and the DNA species are released within their cytosol and leading to STING-dependent DNA sensing. The parasitic DNA then induces type I interferon (IFN) via STING pathway, suggesting a decoy mechanism employed by the parasites from a distance, while growing within the RBCs.
Add to Calendar ▼2017-09-28 11:45:002017-09-28 12:45:00Europe/LondonMalaria Parasites use DNA-Harbouring Vesicles as a Mechanism to Activate Cytosolic Immune SensorsExtracellular Vesicles 2017 in Cripps Court, Magdalene College, Cambridge, UKCripps Court, Magdalene College, Cambridge, UKSELECTBIOenquiries@selectbiosciences.com
