Nikhil Joshi,
Assistant Professor of Immunobiology,
Yale University
Nikhil Joshi received his Ph.D. from the Yale University, where he studied the formation of memory CD8 T cells during acute infections with Susan Kaech. He subsequently joined Tyler Jacks’s laboratory at the Massachusetts Institute of Technology where he investigated regulatory T cells and immunoregulation in the tumor microenvironment in autochthonous models of lung cancer. In 2016, Dr. Joshi moved to the Immunobiology department at Yale University as an assistant professor. His laboratory focuses on how the tumor microenvironments from different cancer types impact the function of anti-tumor T cells and how immune responses shape developing tumors and the tumor microenvironment in genetically engineered mouse cancer models.
Immunosuppression and the Anti-Tumor T cell Response in Natural Tumor Microenvironments
Wednesday, 2 November 2016 at 11:00
Add to Calendar ▼2016-11-02 11:00:002016-11-02 12:00:00Europe/LondonImmunosuppression and the Anti-Tumor T cell Response in Natural Tumor MicroenvironmentsCancer Immunotherapy and Biofluid Biopsies 2016 in Boston, USABoston, USASELECTBIOenquiries@selectbiosciences.com
Immunosuppressive regulatory T cells (Tregs) infiltrate many tumor types, and often this infiltration correlates with poor outcomes for patients. Most investigations of Treg function have focused on lymph nodes (LNs), where Tregs have many functions and suppress responses by many other immune cell types. For much of this regulation, the organized structure of the lymphoid tissue is critical, as Tregs must interact with cells to exert regulation. In the tumor microenvironment (TME) associated with established solid tumors in peripheral organs, like lung cancer however, it is less clear how Tregs regulate other cell types. Our laboratory uses immunocompetent, autochthonous genetically engineered mouse models to investigate Treg function in tumors.
Add to Calendar ▼2016-11-01 00:00:002016-11-02 00:00:00Europe/LondonCancer Immunotherapy and Biofluid Biopsies 2016Cancer Immunotherapy and Biofluid Biopsies 2016 in Boston, USABoston, USASELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2016-11-02 11:00:002016-11-02 12:00:00Europe/LondonImmunosuppression and the Anti-Tumor T cell Response in Natural Tumor MicroenvironmentsCancer Immunotherapy and Biofluid Biopsies 2016 in Boston, USABoston, USASELECTBIOenquiries@selectbiosciences.com
