Imre Mäger,
Postdoctoral Research Scientist and Exosome Team Leader,
University of Oxford
Imre Mäger is a postdoctoral research scientist in Professor Matthew Wood lab in the Department of Physiology, Anatomy and Genetics at the University of Oxford. He also holds a personal research grant of the Estonian Research Council at University of Tartu, Estonia. His primary research is focused on understanding various aspects of extracellular vesicle (EV) biology such as extracellular RNA species and functions, and comparing EV proteome of various cell sources and linking it to EV properties. He also explores strategies for using extracellular vesicles for targeted delivery of biotherapeutics and other types of bioactive drugs.
RNA Binding Proteins and Small RNA Transcriptome of Extracellular Vesicles
Thursday, 28 September 2017 at 14:30
Add to Calendar ▼2017-09-28 14:30:002017-09-28 15:30:00Europe/LondonRNA Binding Proteins and Small RNA Transcriptome of Extracellular VesiclesExtracellular Vesicles 2017 in Cripps Court, Magdalene College, Cambridge, UKCripps Court, Magdalene College, Cambridge, UKSELECTBIOenquiries@selectbiosciences.com
Extracellular vesicles (EVs) mediate specific functions in cell-to-cell communication in health and disease by delivering or displaying biological macromolecules such as proteins and nucleic acids, such as miRNA, to their recipient cells. In order to understand miRNA content in EVs better, in relation to other small RNA species, we conducted next generation sequencing and proteomics experiments of EV samples derived from number of different cell types. Whereas EVs contain significant amount or miRNA, it is not the main EV-associated RNA species even among small RNAs. This is also reflected by the presence of respective RNA binding proteins of EVs. These findings are interesting in the context of EV biology, but also important for EV bioengineering for RNA delivery and for developing EVs for potential biomarkers.
Add to Calendar ▼2017-09-28 14:30:002017-09-28 15:30:00Europe/LondonRNA Binding Proteins and Small RNA Transcriptome of Extracellular VesiclesExtracellular Vesicles 2017 in Cripps Court, Magdalene College, Cambridge, UKCripps Court, Magdalene College, Cambridge, UKSELECTBIOenquiries@selectbiosciences.com
