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SELECTBIO Conferences Circulating Biomarkers World Congress 2018

Jan Lötvall's Biography



Jan Lötvall, Professor Krefting Research Centre, University of Gothenburg, Chief Scientist, Codiak BioSciences; Founding President of ISEV

Jan Lötvall is a professor at University of Gothenburg, Sweden, and is renowned for having discovered the shuttling of RNA between cells by exosomes. He was also intricately involved in starting the International Society for Extracellular Vesicles (www.isev.org), and was the president for this academic association for the period 2011-2016. He has recently taken on new challenges, developing exosomes as therapeutics, with the startup biotech company Codiak BioSciences Inc in Boston.

Professor Lötvall is the Founding President of the International Society of Extracellular Vesicles (ISEV).

Jan Lötvall Image

Subgroups of Extracellular Vesicles from Tumor Tissues for Biomarker Discovery and Liquid Biopsy Development in Malignant Disease

Wednesday, 28 March 2018 at 09:45

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Extracellular vesicles (EVs) have the capacity to shuttle both proteins, lipids and nucleotides such as RNA between cells, leading to an array of functional changes in a recipient cell. Importantly, the EV secretome changes significantly in disease, especially in cancer. We have recently developed a process to isolate EVs specifically from tumor tissues, and have utilized this technology to identify an array of biomarker candidates in malignant melanoma, breast cancer and colon cancer. Specifically, the technique identifies EV surface molecules from tumor tissue EVs, which are not present on plasma EVs from healthy individuals. Using this information, we have been able to develop assays to specifically identify cancer-EVs in the circulation in cancer patients compared to healthy individuals. This presentation will discuss EV diversity, and will give several examples of circulating cancer EV biomarkers that can function as liquid biopsies in cancer subgroup identification, cancer monitoring and putatively cancer screening.


Add to Calendar ▼2018-03-28 00:00:002018-03-29 00:00:00Europe/LondonCirculating Biomarkers World Congress 2018Circulating Biomarkers World Congress 2018 in Boston, USABoston, USASELECTBIOenquiries@selectbiosciences.com