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SELECTBIO Conferences Lab-on-a-Chip and Microfluidics 2020

John Nolan's Biography

John Nolan, CEO, Cellarcus Biosciences, Inc.

Past President of ISAC. ISEV, ISTH Member. Inventor of Cellarcus’ vesicle analysis technologies. Internationally recognized expert in cytometry and vesicle analysis.

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Extracellular Vesicles: Challenges and Opportunities for Single Particle Analysis

Tuesday, 29 September 2020 at 17:00

Add to Calendar ▼2020-09-29 17:00:002020-09-29 18:00:00Europe/LondonExtracellular Vesicles: Challenges and Opportunities for Single Particle AnalysisLab-on-a-Chip and Microfluidics 2020 in Virtual ConferenceVirtual

Extracellular vesicles (EVs) are released by all cells and represent a rich source of potential biomarkers. However, EVs in biofluids such as plasma are extremely heterogeneous, and discriminating informative signal from obscuring noise limits the usefulness of bulk analysis methods such as PCR or Western blot. Single vesicle analysis has the potential to resolve this heterogeneity, but small size and low analyte abundance challenges conventional single particle analysis approaches. Overcoming these challenges will require new measurement tools, including instruments, reagents, and standards that can be integrated into assays with improved sensitivity, specificity, and reproducibility. I will review the state of EV analysis, and highlight new insights provided by high resolution single vesicle flow cytometry (vFC) into the compositional and functional diversity of EVs.

Add to Calendar ▼2020-09-28 00:00:002020-09-30 00:00:00Europe/LondonLab-on-a-Chip and Microfluidics 2020Lab-on-a-Chip and Microfluidics 2020 in Virtual ConferenceVirtual