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SELECTBIO Conferences NGS, SCA, SMA & Mass Spec: Research to Diagnostics 2016

John Nolan's Biography



John Nolan, CEO, Cellarcus Biosciences, Inc.

Past President of ISAC. ISEV, ISTH Member. Inventor of Cellarcus’ vesicle analysis technologies. Internationally recognized expert in cytometry and vesicle analysis.

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Extracellular Vesicles: Mediators of Intercellular Signaling and Potential Biomarkers

Wednesday, 28 September 2016 at 13:30

Add to Calendar ▼2016-09-28 13:30:002016-09-28 14:30:00Europe/LondonExtracellular Vesicles: Mediators of Intercellular Signaling and Potential BiomarkersNGS, SCA, SMA and Mass Spec: Research to Diagnostics 2016 in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com

Extracellular vesicles (EVs) are attracting attention as potential biomarkers because they contain molecular cargo from their cell of origin that might reveal information about health and disease. However, EVs are hard to measure because they are small and heterogeneous. Flow cytometry, which can resolve heterogeneity in populations of cells, struggles to measures small, dim EVs. Recent developments in flow cytometry instrumentation and assay design enable us to quantitatively detect, size, and analyze the cargo of individual EVs and to catalogue their diversity. This approach allows EVs to be measured directly in diluted biofluids without the need for wash steps. I will report on the numbers and molecular diversity of EVs in plasma, CSF, and urine, and the variations observed in disease models and patient samples.


Add to Calendar ▼2016-09-26 00:00:002016-09-28 00:00:00Europe/LondonNGS, SCA, SMA and Mass Spec: Research to Diagnostics 2016NGS, SCA, SMA and Mass Spec: Research to Diagnostics 2016 in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com