Mario Gimona,
Head of Manufacturing, GMP Unit,
Paracelsus Medical University Salzburg
Mario Gimona received his PhD in Genetics and Cell Biology in 1990 and spent his postdoctoral period at the Cold Spring Harbor Laboratory in New York. He has led research labs in Austria and Italy and was awarded a Marie Curie Excellent Grant by the European Union in 2004. Since 2012 he heads the GMP stem cell and EV production unit at PMU and leads a team of researchers investigating the potential of MSC-derived EVs and CDVs in regenerative medicine for application in acute spinal cord injury and for the reduction of scar formation following implant-induced injury.
EV-based Therapeutics Development: No Place for the Weak
Monday, 24 June 2024 at 17:00
Add to Calendar ▼2024-06-24 17:00:002024-06-24 18:00:00Europe/LondonEV-based Therapeutics Development: No Place for the WeakCirculating Biomarkers and Extracellular Vesicles Europe 2024 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
Extracellular vesicle (EV)-enriched preparations obtained from multipotent mesenchymal stromal cells (MSCs) are of particular interest for therapeutic use since they may convey anti-inflammatory, anti-fibrotic and cyto-protective activities to the target tissues. MSCs secrete a variety of bioactive autocrine and paracrine factors including cytokines, chemokines, extracellular matrix proteins, EVs and growth factors. The circulating MSC-derived secretome is thus a complex mixture of proteins, lipids, macromolecular assemblies and vesicular structures, including various types of EVs. Current activities aim at quantitatively describing one or more biological activities present in/on EVs that are beneficial in elucidating the complex mechanism-of-action of the vesicular secretome, and that can assist in the required dose-finding for pre-clinical and clinical application. Understanding EV composition and dynamics will further increase the value of these nanosized particles as a potential tool for companion diagnostics.
Add to Calendar ▼2024-06-24 00:00:002024-06-25 00:00:00Europe/LondonCirculating Biomarkers and Extracellular Vesicles Europe 2024Circulating Biomarkers and Extracellular Vesicles Europe 2024 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2024-06-24 17:00:002024-06-24 18:00:00Europe/LondonEV-based Therapeutics Development: No Place for the WeakCirculating Biomarkers and Extracellular Vesicles Europe 2024 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
