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SELECTBIO Conferences Extracellular Vesicles (EVs: Exosomes and Microvesicles): Research, Diagnostics and Therapeutics Applications

Tony Jun Huang's Biography

Tony Jun Huang, Professor of Mechanical Engineering and Materials Science (MEMS), Pratt School of Engineering, Duke University

Tony Jun Huang is a professor at Department of Mechanical Engineering and Materials Science (MEMS) at Duke University. Previously he was a professor and The Huck Distinguished Chair in Bioengineering Science and Mechanics at The Pennsylvania State University. He received his Ph.D. degree in Mechanical and Aerospace Engineering from the University of California, Los Angeles (UCLA) in 2005. His research interests are in the fields of acoustofluidics, optofluidics, and micro/nano systems for biomedical diagnostics and therapeutics. He has authored/co-authored over 180 peer-reviewed journal publications in these fields. His journal articles have been cited more than 10,000 times, as documented at Google Scholar (h-index: 55). He also has 17 patents and invention disclosures. He was elected a fellow of the following five professional societies: the American Institute for Medical and Biological Engineering (AIMBE), the American Society of Mechanical Engineers (ASME), the Institute of Electrical and Electronics Engineers (IEEE), the Institute of Physics (IOP), and the Royal Society of Chemistry (RSC). His work have been recognized with awards and honors such as a 2010 National Institutes of Health (NIH) Director’s New Innovator Award, a 2011 Penn State Engineering Alumni Society Outstanding Research Award, a 2011 JALA Top Ten Breakthroughs of the Year Award, a 2012 Outstanding Young Manufacturing Engineer Award from Society for Manufacturing Engineering, a 2013 Faculty Scholar Medal from The Pennsylvania State University, a 2013 American Asthma Foundation (AAF) Scholar Award, the 2014 IEEE Sensors Council Technical Achievement Award from The Institute of Electrical and Electronics Engineers (IEEE), and the 2017 Analytical Chemistry Young Innovator from the American Chemical Society.

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Acoustic Tweezers: Separating Exosomes, Circulating Tumor Cells, and Other Tiny Objects Using Sound Waves

Thursday, 29 March 2018 at 15:00

Add to Calendar ▼2018-03-29 15:00:002018-03-29 16:00:00Europe/LondonAcoustic Tweezers: Separating Exosomes, Circulating Tumor Cells, and Other Tiny Objects Using Sound

The ability to isolate exosomes, circulating tumor cells (CTCs), and other circulating factors from biological fluids in a precise, biocompatible, and convenient manner is critical for many biomedical studies and applications. Here we summarize our recent progress on an “acoustic tweezers” technology that utilizes sound waves to manipulate exosomes, CTCs, and other tiny particles. For example, we developed an acoustic separation method to isolate exosomes directly from undiluted whole blood in a label-free and contact-free manner. This device consists of two modules. Micro-scale blood components are first removed by the cell-removal module, followed by extracellular vesicle subgroup separation in the exosome-isolation module. In the cell-removal module, we demonstrate the isolation of 110 nm particles from a mixture of micro- and nano-sized particles with a yield greater than 99%. In the exosome-isolation module, we isolate exosomes from an extracellular vesicle mixture with a purity of 98.4%. Integrating the two acoustofluidic modules onto a single chip, we isolated exosomes from whole blood with a blood cell removal rate of over 99.999%. The acoustic tweezers technology is capable of delivering high-precision, high-throughput, high-efficiency cell/particle/fluid manipulation in a simple, inexpensive, cell-phone-sized device. More importantly, the acoustic power intensity and frequency used in the acoustic tweezers technology are in a similar range as those used in ultrasonic imaging, which has proven to be extremely safe for health monitoring, even during various stages of pregnancy. As a result, the acoustic tweezers technology is extremely biocompatible; i.e., cells can maintain their natural states and highest integrity during the acoustic cell-manipulation process.

Add to Calendar ▼2018-03-28 00:00:002018-03-29 00:00:00Europe/LondonExtracellular Vesicles (EVs: Exosomes and Microvesicles): Research, Diagnostics and Therapeutics