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SELECTBIO Conferences Innovations in Microfluidics 2020

Balaji Panchapakesan's Biography

Balaji Panchapakesan, Professor, Department of Mechanical Engineering, Worcester Polytechnic Institute (WPI)

Dr. Balaji Panchapakesan is a Professor of Mechanical Engineering at Worcester Polytechnic Institute in Worcester, MA. He invented the Nanotube-CTC-Chip microarray technology. He has published over 100 articles in leading journals, and conferences. He is a conference chair of the SPIE Nanoscience and Engineering conference. His interests are in enabling nanoscience for wide variety of applications including capture of circulating biomarkers.

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Liquid Biopsy using Nanotube-CTC-Chip

Tuesday, 18 August 2020 at 14:30

Add to Calendar ▼2020-08-18 14:30:002020-08-18 15:30:00Europe/LondonLiquid Biopsy using Nanotube-CTC-ChipInnovations in Microfluidics 2020 in Boston, USABoston,

We report the further development of the nanotube-CTC-chip for isolation of tumor-derived epithelial cells (circulating tumor cells, CTCs) from peripheral blood, with high purity, by exploiting the physical mechanisms of preferential adherence of CTCs on a nanotube surface. The nanotube-CTC-chip is a new 76-element microarray technology that combines carbon nanotube surfaces with microarray batch manufacturing techniques for the capture and isolation of tumor-derived epithelial cells. Using a combination of red blood cell (RBC) lysis and preferential adherence, we demonstrate the capture and enrichment of CTCs with a 5-log reduction of contaminating WBCs. The nanotube-CTC-chip successfully captured CTCs in the peripheral blood of breast cancer patients (stage 1–4) with a range of 4–238 CTCs per 8.5 ml blood or 0.5–28 CTCs per ml. CTCs (based on CK8/18, Her2, EGFR) were successfully identified in breast cancer patients, and no CTCs were captured in healthy controls. CTC enumeration based on multiple markers using the nanotube-CTC-chip enables dynamic views of metastatic progression and could potentially have predictive capabilities for diagnosis and treatment response.

Add to Calendar ▼2020-08-17 00:00:002020-08-18 00:00:00Europe/LondonInnovations in Microfluidics 2020Innovations in Microfluidics 2020 in Boston, USABoston,