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SELECTBIO Conferences 3D-Printing and Biofabrication 2020

Jungwoo Lee's Biography

Jungwoo Lee, Assistant Professor, University of Massachusetts-Amherst

Jungwoo Lee is an assistant professor in the Department of Chemical Engineering and a principle investigator at the Institute for Applied Life Sciences at the University of Massachusetts-Amherst. He received his Ph.D. in Biomedical Engineering at the University of Michigan and post-doctoral training at the Center for Engineering in Medicine, Massachusetts General Hospital and Shriners Hospitals in Children at Boston. He has published over 35 research papers in the field of biomaterials and tissue engineering (H-index=29, > 3,500 citations). With core expertise in biomaterials, micro-fabrication, cellular engineering, and biomedical imaging, his lab aims to develop tissue-engineered hematopoietic bone marrow models. These models are applied for better understanding the bone marrow tissue microenvironments and associated stem cell and cancer biology. His research has been supported by National Cancer Institute.

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Additive Manufacturing of 3D Bone Tissue Model

Tuesday, 18 August 2020 at 15:30

Add to Calendar ▼2020-08-18 15:30:002020-08-18 16:30:00Europe/LondonAdditive Manufacturing of 3D Bone Tissue Model3D-Printing and Biofabrication 2020 in Boston, USABoston,

Creating functional bone tissue analogs outside of the body represents a unique opportunity to understand bone biology better. Various biomaterials and engineering strategies have been developed, but a realistic bone tissue model that reproduces both surface and subsurface cellular and extracellular matrix complexity remain unsuccessful. Mature bone consists of multiple lamellar bones interfaced with osteocytes that are primary mechanosensory cells. In this presentation, I will introduce a new approach to create bone tissue replica by additive manufacturing of the lamellar structure of bone. We first developed a process to generate a thin section of demineralized compact bone that supports the aligned adhesion of osteoblasts and structural mineral deposition. We then exploited tissue-engineering strategies to induce osteoblast-to-osteocyte differentiation via stacking multiple layers of osteoblasts pre-seeded demineralized bone paper and subsequently applying cyclic mechanical compression under hypoxic milieu. Our additive manufacturing of bone tissue demonstrated precise control of the thickness and both surface and subsurface cellular complexity. We envision that the presented additive manufacturing bone tissue models is expected to greatly advance bioengineering trabecular bone for basic and applied researches.

Add to Calendar ▼2020-08-17 00:00:002020-08-18 00:00:00Europe/London3D-Printing and Biofabrication 20203D-Printing and Biofabrication 2020 in Boston, USABoston,