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SELECTBIO Conferences Innovations in Microfluidics, Biofabrication, Synthetic Biology

Jungwoo Lee's Biography

Jungwoo Lee, Assistant Professor, University of Massachusetts-Amherst

Jungwoo Lee is an assistant professor in the Department of Chemical Engineering and a principle investigator at the Institute for Applied Life Sciences at the University of Massachusetts-Amherst. He received his Ph.D. in Biomedical Engineering at the University of Michigan and post-doctoral training at the Center for Engineering in Medicine, Massachusetts General Hospital and Shriners Hospitals in Children at Boston. He has published over 35 research papers in the field of biomaterials and tissue engineering (H-index=29, > 3,500 citations). With core expertise in biomaterials, micro-fabrication, cellular engineering, and biomedical imaging, his lab aims to develop tissue-engineered hematopoietic bone marrow models. These models are applied for better understanding the bone marrow tissue microenvironments and associated stem cell and cancer biology. His research has been supported by National Cancer Institute.

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Development of in vitro Mucosal Interface in a Multi-well Plate

Monday, 26 March 2018 at 15:00

Add to Calendar ▼2018-03-26 15:00:002018-03-26 16:00:00Europe/LondonDevelopment of in vitro Mucosal Interface in a Multi-well

The gastrointestinal tract (GIT) accounts for more than 75% of the body surface that directly contact with daily ingested foods along with microbes to absorb nutrients and water while keeping essential barrier function. This makes the GIT the prime site for the host-microbiome interactions where the host deploys about 80% of immune cells to protect and maintain homeostasis. The GIT epithelium consists of a monolayer of polarized cells arranged into microscopic features that increase the GIT surface area tremendously. Recent studies suggest that peristaltic motion would be critical for epithelial cell differentiation, polarization and structural arrange-ment into villi and crypts. Some progress has been made in recent times, there is still a growing need to develop model systems to integrate microbiome, epithelial cells, and immune cells in a single platform along with providing sufficient level of biological and mechanical complexity. To this end, we developed a mechanically actuated 3D tissue culture model system that can achieve the aforementioned integration of different cell types with multiple layer complexity in an easily adaptable well plate platform. In this study we demonstrate how this platform was used to mechanically stimulate colon carcinoma cells (HT-29) leading to polarization, vertical growth and 3D morphogenesis of these cells.

Add to Calendar ▼2018-03-26 00:00:002018-03-27 00:00:00Europe/LondonInnovations in Microfluidics, Biofabrication, Synthetic