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SELECTBIO Conferences Biofabrication & Biomanufacturing Europe 2019

Yan Yan Shery Huang's Biography

Yan Yan Shery Huang, University Lecturer in Bioengineering, University of Cambridge

Shery Huang completed her MEng degree in Materials Science and Engineering from Imperial College London in 2007 (1st Class; top of the class). With a Cambridge Gates Scholarship, she then pursued a PhD in Physics at Cambridge, focusing on nanotechnology. After graduating from her PhD in 2011, she was awarded an Oppenheimer Fellowship and a Homerton College Junior Research Fellowship. Since Aug 2013, she is a University Lecturer in Bioengineering at Cambridge. She was the lead organizer for the Biofabrication Symposium at the MRS 2016 Spring Conference. She was also selected as one of the 26 women to present at ‘The Meaning of Success: Insights from Women at Cambridge'.

Yan Yan Shery Huang Image

Engineering Airway Tubes via Guided Self-Assembly

Friday, 21 June 2019 at 08:30

Add to Calendar ▼2019-06-21 08:30:002019-06-21 09:30:00Europe/LondonEngineering Airway Tubes via Guided Self-AssemblyBiofabrication and Biomanufacturing Europe 2019 in Rotterdam, The NetherlandsRotterdam, The

Organoids are self-organizing micro-tissues that mimic the basic structure and function of an organ unit. In recent years, organoids have become instrumental for the study of organ development, function and disease. They have also become an important assay system for testing therapeutic approaches.  Epithelial organoids grown from isolated, single stem cells in a three-dimensional Matrigel® culture typically develop into a microscopic cystic structure with a polarised epithelium and a hollow centre. Here, we use adult basal stem cells of the mouse trachea to introduce a simple protocol for guided organoid self-assembly, to generate macroscopic, single lumen organoids with the aim to engineer larger tissue units. The engineering process results in a high success rate that gives rise to macroscopic tube-like structures with several millimetres in length. Here we analyse the assembly process by immunohistochemistry and time-lapse imaging. Our preliminary work shows that this engineered organoid assembly process opens up the possibility for generating a perfusable trachea-on-a-chip.

Add to Calendar ▼2019-06-20 00:00:002019-06-21 00:00:00Europe/LondonBiofabrication and Biomanufacturing Europe 2019Biofabrication and Biomanufacturing Europe 2019 in Rotterdam, The NetherlandsRotterdam, The