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SELECTBIO Conferences Biofabrication & Biomanufacturing Europe 2019

Yan Yan Shery Huang's Biography

Yan Yan Shery Huang, Professor of BioEngineering, University of Cambridge

Dr. Huang is Professor of BioEngineering, University of Cambridge. She completed her MEng degree in Materials Science and Engineering from Imperial College London in 2007. She then pursued a PhD in Physics at Cambridge. She was a visiting researcher at University of Texas at Austin (2008), and an Oppenheimer Fellow and a Homerton College Junior Research Fellow (2011-2013). She is a recipient of the prestigious ERC Starting grant, and a fellow of the Institute of Fellow of the Institute of Materials, Minerals and Mining, UK.

Yan Yan Shery Huang Image

Engineering Airway Tubes via Guided Self-Assembly

Friday, 21 June 2019 at 08:30

Add to Calendar ▼2019-06-21 08:30:002019-06-21 09:30:00Europe/LondonEngineering Airway Tubes via Guided Self-AssemblyBiofabrication and Biomanufacturing Europe 2019 in Rotterdam, The NetherlandsRotterdam, The

Organoids are self-organizing micro-tissues that mimic the basic structure and function of an organ unit. In recent years, organoids have become instrumental for the study of organ development, function and disease. They have also become an important assay system for testing therapeutic approaches.  Epithelial organoids grown from isolated, single stem cells in a three-dimensional Matrigel┬« culture typically develop into a microscopic cystic structure with a polarised epithelium and a hollow centre. Here, we use adult basal stem cells of the mouse trachea to introduce a simple protocol for guided organoid self-assembly, to generate macroscopic, single lumen organoids with the aim to engineer larger tissue units. The engineering process results in a high success rate that gives rise to macroscopic tube-like structures with several millimetres in length. Here we analyse the assembly process by immunohistochemistry and time-lapse imaging. Our preliminary work shows that this engineered organoid assembly process opens up the possibility for generating a perfusable trachea-on-a-chip.

Add to Calendar ▼2019-06-20 00:00:002019-06-21 00:00:00Europe/LondonBiofabrication and Biomanufacturing Europe 2019Biofabrication and Biomanufacturing Europe 2019 in Rotterdam, The NetherlandsRotterdam, The