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SELECTBIO Conferences Fragment Based Lead Discovery

Iwan De Esch's Biography



Iwan De Esch, Associate Professor, VU University Amsterdam

Dr Iwan de Esch did his PhD research at the Department of Pharmacochemistry, VU University Amsterdam, The Netherlands. In 1998, he became research associate at the Drug Design Group of the University of Cambridge. Dr de Esch is a co-founder of De Novo Pharmaceuticals (2000) where he worked as a group and project leader. Dr de Esch returned to academia in 2003 and is now associate professor at the Medicinal Chemistry Department. The group focuses on two research lines, namely G-protein-coupled receptors (GPCRs) and fragment-based drug design (FBDD). Dr. de Esch is also co-founder of IOTA Pharmaceuticals Ltd (2007) and Griffin Discoveries BV (2009). In 2011, he was awarded the Galenus Research Price for his work on FBDD.

Iwan De Esch Image

Fragment Based Design, Synthesis and Pharmacological Evaluation of Potent Inhibitors of Trypanosomal Phosphodiesterase B1

Wednesday, 20 March 2013 at 14:15

Add to Calendar ▼2013-03-20 14:15:002013-03-20 15:15:00Europe/LondonFragment Based Design, Synthesis and Pharmacological Evaluation of Potent Inhibitors of Trypanosomal Phosphodiesterase B1SELECTBIOenquiries@selectbiosciences.com

In this presentation I will discuss the fragment-based approaches which were used to grow the structure of a Trypanosoma brucei phosphodiesterases (TbrPDE) hit into a parasite specific binding pocket, leading to potent inhibitors that have potential as new treatment of African sleeping sickness. 


Add to Calendar ▼2013-03-19 00:00:002013-03-20 00:00:00Europe/LondonFragment Based Lead Discovery SELECTBIOenquiries@selectbiosciences.com