Matthew Baker,
Assistant Professor, MERLN Institute,
Maastricht University
Matt Baker's research interests include the synthesis and characterization of novel and dynamic materials to mimic the cellular environment and to create advanced soft materials. Of particular interest is the use of reversible supramolecular interactions (e.g. host-guest, supramolecular polymers, hydrogen bonding) to build these materials and the use of mechanochemistry to influence a material’s properties and living systems. Matt received his B.S. in chemistry (2006) at Clemson University in the United States and worked shortly for Tetramer Technologies, LLC, a start-up company commercializing novel fluoropolymers developed at Clemson University. He obtained his PhD in 2012 in Physical Organic Chemistry under the guidance of Ronald K. Castellano at the University of Florida and then moved to Eindhoven University of Technology to design and characterize water soluble supramolecular polymers under guidance of Prof. E. W. Meijer. In 2015, Matt joined the MERLN institute as a researcher, while also starting a group to explore the utility of dynamic interactions in biomaterials. In 2017, he was promoted to Assistant Professor, founding a group to rationally design, synthesize, and characterize biomaterials based around stimuli-responsive and dynamic interactions. Currently, he serves as the group’s biggest fan, and aims to train scientists at the interface of Chemistry and Bioengineering. The work of the group has been recognized by the American Chemical Society with our lab being named a 2021 PMSE Young Investigator.
(Supra)Molecular Design Enables Advanced Bioinks and Extracellular Matrix Mimietics
Tuesday, 8 November 2022 at 09:30
Add to Calendar ▼2022-11-08 09:30:002022-11-08 10:30:00Europe/London(Supra)Molecular Design Enables Advanced Bioinks and Extracellular Matrix MimieticsBioprinting and Bioink Innovations for 3D-Tissues 2022 in Boston, USABoston, USASELECTBIOenquiries@selectbiosciences.com
While natural systems have evolved elegant self-assembled materials, the recreation of such materials in a synthetic system remains a challenge. Even more challenging is leveraging these delicate and hierarchically assembled structures for advanced biomedical engineering technologies. Supramolecular materials utilized for tissue engineering often suffer from poor mechanical properties and poor fabrication performance. In order to address these challenges, we set out to create supramolecular hydrogels from benzene-1,3,5-tricarboxamides which could be amenable to cell-culture and 3D fabrication technologies. Due to the dynamic nature of these supramolecular hydrogels, we paid careful attention to strategies to tune the dynamics and viscoelastic parameters of the system, enabling hydrogels with 1D nanofiber features and controllable internal dynamics. By carefully controlling the timescales of the material, we could access ranges that allowed control over cell aggregate formation and 3D printing. Ultimately, due to their self-healing and injectable nature, these materials were amenable to 3D bioprinting, and could be utilized to create complex architectures like a human sized meniscus. Via careful supramolecular design, the cooperative effects of supramolecular hierarchical structure and control over dynamic timescales can lead to highly processable and biomimetic architectures interesting for tissue engineering.
Add to Calendar ▼2022-11-07 00:00:002022-11-08 00:00:00Europe/LondonBioprinting and Bioink Innovations for 3D-Tissues 2022Bioprinting and Bioink Innovations for 3D-Tissues 2022 in Boston, USABoston, USASELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2022-11-08 09:30:002022-11-08 10:30:00Europe/London(Supra)Molecular Design Enables Advanced Bioinks and Extracellular Matrix MimieticsBioprinting and Bioink Innovations for 3D-Tissues 2022 in Boston, USABoston, USASELECTBIOenquiries@selectbiosciences.com
