Pavel Ivanov's Biography

Pavel Ivanov, Associate Member, Broad Institute of Harvard and MIT; Associate Immunologist at Brigham and Women’s Hospital

My research focuses on the basic and translational aspects of RNA metabolism in age-related diseases. A unifying aspect of this theme is RNA-mediated stress responses on the post-transcriptional level. I am interested in understanding the: (1) mechanisms and consequences of stress-induced/regulated RNA cleavage in cell physiology and their relation to cancer and neuro-degeneration; (2) roles of RNA granules in adaptation to stress and their contribution to the development of patho-physiological conditions (inflammation, cancer, and neuro-degeneration); and (3) roles of stress-induced non-coding RNAs and stress-regulated RNA-binding proteins in cancer and neuro-degeneration.