| Conferences \ The RNA Summit: Research, Diagnostics & Therapeutics \ Agenda \ Suet Yan Kwan |
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Using CRISPR Screens to Find Drug Targets in Liver CancerTuesday, 14 November 2017 at 14:00  Add to Calendar ▼2017-11-14 14:00:002017-11-14 15:00:00Europe/LondonUsing CRISPR Screens to Find Drug Targets in Liver CancerThe RNA Summit: Research, Diagnostics and Therapeutics in Boston, USABoston, USASELECTBIOenquiries@selectbiosciences.comHepatocellular carcinoma is the third-leading cause of cancer-death worldwide. The current treatment for hepatocellular carcinoma is limited to surgery and sorafenib depending on the stage of the disease. However, the majority of patients are not eligible for surgery and the prognosis for patients receiving sorafenib treatment is poor. Therefore, additional drug targets are desperately needed for treatment of hepatocellular carcinoma. To identify additional drug targets in liver cancer, we performed a kinome CRISPR/sgRNA screen in three hepatocellular carcinoma cell lines and compared sgRNA representation between early and late passages. By finding sgRNAs that are depleted at late passages, we can identify potential kinases that are required for cell growth in hepatocellular carcinoma. |
Add to Calendar ▼2017-11-13 00:00:002017-11-14 00:00:00Europe/LondonThe RNA Summit: Research, Diagnostics and TherapeuticsThe RNA Summit: Research, Diagnostics and Therapeutics in Boston, USABoston, USASELECTBIOenquiries@selectbiosciences.com
