Yael Heifetz's Biography

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Successful Implantation: How Small Molecule Dynamics Play a Big Role in Cell-Cell Communication

Thursday, 25 October 2018 at 17:00

Add to Calendar ▼2018-10-25 17:00:002018-10-25 18:00:00Europe/LondonSuccessful Implantation: How Small Molecule Dynamics Play a Big Role in Cell-Cell CommunicationExosomes and Liquid Biopsies Europe 2018 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com

Embryo-maternal communication is crucial for achieving successful pregnancy and for the future health of the progeny. A relay of molecular signals between mother and gametes is critical as soon as after copulation, during gamete transport in the female reproductive tract, gamete maturation, and fertilization. The next step, the process of embryo implantation, is a major obstacle for successful maintenance of pregnancy to term. For implantation to succeed, a synchronized network of molecular interactions between mother and embryo must occur. Although key molecules have been identified, we still lack comprehensive understanding of the early dynamics of implantation which set-up the stage for a successful pregnancy. To examine the early sequence of events that initiate the embryo-maternal cross-talk we used in-vitro (human endometrial and trophoblast cell lines) and in-vivo (domestic pig Susscrofa domestica) models, and various molecular and imaging approaches to monitor the spatial and temporal dynamics of intercellular interactions. This talk will focus on extracellular vesicles (EVs), which have been suggested to act as essential mediators of embryo-maternal communication. Studying the dynamics of the cross-talk, and specifically signals that promote successful implantation at an early stage, will shed more light on the implantation process and possibly guide new strategies in diagnosing and preventing implantation failure.