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SELECTBIO Conferences 3D Culture Models

Evan Cromwell's Biography

Evan Cromwell, President & CEO, Protein Fluidics

Dr. Cromwell is a successful entrepreneur and an innovative leader of instrument and assay product development teams. He has 30 years of senior executive and technical experience in research, engineering, bioassay development, production, and marketing. Prior to founding Protein Fluidics, he served as Director of Research at Molecular Devices and was a leader of a cross-OpCo scientific team for the Danaher Life Sciences group. He was Founder and President of Blueshift Biotechnologies, a high-content screening and analysis venture that was acquired by Molecular Devices in 2008. His passion is integrating new technologies into products that provide unexpected value to customers in life sciences and other communities. He holds a B.S. in Chemistry from Caltech and earned his Ph.D. in Physical Chemistry at the University of California, Berkeley. He has authored 40+ publications in the fields of biology, physical chemistry, and optical instrumentation and holds 16 patents.

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Automated Sampling of Patient-Derived 3D Cell Models for Metabolite Analysis

Thursday, 9 September 2021 at 14:15

Add to Calendar ▼2021-09-09 14:15:002021-09-09 15:15:00Europe/LondonAutomated Sampling of Patient-Derived 3D Cell Models for Metabolite Analysis3D Culture Models in Virtual Event - Eastern Daylight Time (EDT) ZoneVirtual Event - Eastern Daylight Time (EDT)

The use of patient-derived (PD) cells provides a more physiologically relevant system for drug discovery and development.   Incorporating these into 3D cell models creates a translational tool that can recapitulate the genetic and molecular compositions of tissues such as solid cancers.  However, the complexity of performing assays with such models remains a hurdle for the wider adoption in research and drug screening.  Metabolite analysis, in particular, is challenging due to cellular sensitivity to external factors and the dynamic nature of cell metabolism.  This presentation will discuss a novel method of automated time-course sampling of supernatants from 3D cell models coupled with highly sensitive luminescence-based assays for important metabolites such as lactate and glutamate.   We show the use of this system for profiling metabolism response of PD tumoroids to different treatments and its use in disease modeling.   This system with PD tumoroids is a useful tool to improve efficiency for studies of drug sensitivity studies from individual tumor types to specific drug classes, with implication for future development in personalized medicine.

Add to Calendar ▼2021-09-09 00:00:002021-09-09 00:00:00Europe/London3D Culture Models3D Culture Models in Virtual Event - Eastern Daylight Time (EDT) ZoneVirtual Event - Eastern Daylight Time (EDT)