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SELECTBIO Conferences High-Content and Phenotypic Screening Europe 2018

Matthew Daniels's Biography

Matthew Daniels, Wellcome Trust Intermediate Clinical Fellow, Honorary Consultant Cardiologist, University of Oxford

Matthew is an academic cardiologist currently supported by the Wellcome Trust to develop iPS models of inherited human heart disease and better ways to study them at the University of Oxford, UK. While enrolled on the Astra-Zeneca funded MB-PhD program at the University of Cambridge he developed an interest in live cell imaging and fluorescent protein technology, enabling the first observation of failure of cytokinesis causing aneuploidy in inherited human cancer (Daniels et al, Science, 2004, 306, 876-9). He then went on to train in clinical cardiology developing an internationally recognised practice in structural intervention and inherited cardiac conditions. His academic activity is currently focused on development and application of genetically encoded tools to study excitable cells, improving how these platforms can be used for rare disease drug discovery and toxicology evaluation. His career aim is to develop cell based repair of the human heart using percutaneous intracardiac devices to carry cells to the site of repair.

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iPSC-based Models of Heart Disease – How to Make Them and Study Them Properly

Thursday, 24 May 2018 at 11:00

Add to Calendar ▼2018-05-24 11:00:002018-05-24 12:00:00Europe/LondoniPSC-based Models of Heart Disease – How to Make Them and Study Them ProperlyHigh-Content and Phenotypic Screening Europe 2018 in Cambridge, UKCambridge,

Many iPSc based models of inherited heart disease are now available, but very little has been done to improve the way they are analyzed. I will demonstrate an example of iPS to validate a whole genome sequencing result, and show how various contemporary phenotyping strategies fail but can be improved.

Add to Calendar ▼2018-05-24 00:00:002018-05-25 00:00:00Europe/LondonHigh-Content and Phenotypic Screening Europe 2018High-Content and Phenotypic Screening Europe 2018 in Cambridge, UKCambridge,