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SELECTBIO Conferences Organ-on-a-Chip & Tissue-on-a-Chip Europe 2019

Nikolce Gjorevski's Biography

Nikolce Gjorevski, Scientist, Mechanistic Safety, Pharmaceutical Sciences, Roche Innovation Center Basel

After receiving an undergraduate degree in chemical engineering at Lafayette College, I enrolled in the graduate chemical and biological engineering program at Princeton University. Mentored by Celeste Nelson, I used novel tissue microfabrication approaches to study mammary gland development and disease quantitatively. After completing my PhD at Princeton, I received an EMBO Long-Term Postdoctoral Fellowship to carry out postdoctoral work, in the group of Matthias Lutolf at EPFL. In Lausanne, I used modular synthetic hydrogels to dissect the regulation of intestinal stem cell fate by the ECM, and designed well-defined alternatives to natural matrices for the culture of epithelial stem cells and organoids. I began a Scientist position at Roche in 2018, joining the company’s effort to establish advanced cellular models and microphysiological systems as platforms for drug discovery.

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Immunocompetent Gut-on-a-Chip as a Model of Tissue Inflammation

Wednesday, 19 June 2019 at 12:00

Add to Calendar ▼2019-06-19 12:00:002019-06-19 13:00:00Europe/LondonImmunocompetent Gut-on-a-Chip as a Model of Tissue InflammationOrgan-on-a-Chip and Tissue-on-a-Chip Europe 2019 in Rotterdam, The NetherlandsRotterdam, The

Owing to its complex and multifactorial nature, inflammatory bowel disease (IBD) remains poorly understood, which, in turn, renders the development of effective IBD therapies a major challenge. The poor translatability of IBD therapeutics from mice to humans may be attributed in large part to the fundamental immunological differences between the two species. Advanced three-dimensional (3D) culture models and microphysiological systems are emerging as superior alternatives to animals in capturing human-specific physiology and disease. We have created an immune-competent gut-on-a-chip model comprising a tight intestinal epithelial barrier, extracellular matrix, resident and circulating immune cells. Beyond a mere co-culture, the system recapitulates the crucial multidirectional interactions between matrix, parenchymal and immune cells that generate an inflammatory milieu and ultimately result in epithelial damage in the context of IBD. The physiological completeness of the model may help afford fundamental insight into the mechanisms that drive chronic inflammation in the gut and other organs, ultimately supporting drug discovery.

Add to Calendar ▼2019-06-18 00:00:002019-06-19 00:00:00Europe/LondonOrgan-on-a-Chip and Tissue-on-a-Chip Europe 2019Organ-on-a-Chip and Tissue-on-a-Chip Europe 2019 in Rotterdam, The NetherlandsRotterdam, The