| Conferences \ Organ-on-a-Chip, Tissue-on-a-Chip & Organoids Europe 2020 \ Agenda \ Marius Busche |
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HepaChip-MP – An organ-like Perfusable Cell Culture System in Multi-well Plate Format for Toxicity TestingThursday, 10 September 2020 at 11:00  Add to Calendar ▼2020-09-10 11:00:002020-09-10 12:00:00Europe/LondonHepaChip-MP – An organ-like Perfusable Cell Culture System in Multi-well Plate Format for Toxicity TestingOrgan-on-a-Chip, Tissue-on-a-Chip and Organoids Europe 2020 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.comWe present a microfluidic, continuously perfused in vitro model of the liver-sinusoid in multiwellplate format (HepaChip-MP). Electrodes integrated within the system enable active and simultaneous assembly of only viable liver cells into sinusoid-like structures within 24 independent cultivation chambers. Automated filling by a pipetting robot and tubeless gravitational driven perfusion yields an easy-to-use system operable by non-expert end-users. Reduced vitality after diclofenac treatment could be measured and metabolic functions such as CYP activity and CYP induction were demonstrated. Integrated oxygen sensors allow to measure oxygen concentration and cellular respiration inside the culture chamber. |
Add to Calendar ▼2020-09-09 00:00:002020-09-10 00:00:00Europe/LondonOrgan-on-a-Chip, Tissue-on-a-Chip and Organoids Europe 2020Organ-on-a-Chip, Tissue-on-a-Chip and Organoids Europe 2020 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
