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SELECTBIO Conferences 3D-Bioprinting and Tissue Engineering

Bhushan Mahadik's Biography

Bhushan Mahadik, Assistant Director, NIH/NIBIB Center for Engineering Complex Tissues, University of Maryland

Dr. Mahadik is the Assistant Director for CECT, and is at the University of Maryland. He received his Ph.D. in Chemical and Biomolecular Engineering under Prof. Harley from UIUC in 2014 and his B.S. in Chemical and Materials Science Engineering from the University of California, Berkeley in 2008. His research background spans tissue engineering techniques aimed at developing 3D biomaterial platforms to engineer the hematopoietic stem cell (HSC) niche, studying the effects of the bone marrow microenvironment on stem cell biology, and utilizing microfluidics-based and 3D printing biofabrication techniques to design patterned, hetergoeneous tissues. His research interests involve the use of Biomedical and Tissue Engineering approaches in translational science to develop clinically relevant therapies for patients.

Bhushan Mahadik Image

3D Printing for Engineering Complex Tissues

Monday, 26 March 2018 at 10:30

Add to Calendar ▼2018-03-26 10:30:002018-03-26 11:30:00Europe/London3D Printing for Engineering Complex

The generation of complex tissues has been an increasing focus in tissue engineering and regenerative medicine.  With recent advances in bioprinting technology, our laboratory has focused on the development of platforms for the treatment and understanding of clinically relevant problems ranging from congenital heart disease to preeclampsia.  We utilize stereolithography-based and extrusion-based additive manufacturing to generate patient-specific vascular grafts, prevascular networks for bone tissue engineering, dermal dressings, cell-laden models of preeclampsia, and bioreactors for expansion of stem cells.  Furthermore, we have developed a range of UV crosslinkable materials to provide clinically relevant 3D printed biomaterials with tunable mechanical properties.  Such developments demonstrate the ability to generate biocompatible materials and fabricated diverse structures from natural and synthetic biomaterials.  In addition, one of the key challenges associated with the development of large tissues is providing adequate nutrient and waste exchange.  By combining printing and dynamic culture strategies, we have developed new methods for generating macrovasculature that will provide adequate nutrient exchange in large engineered tissues.  Finally, the use of stem cells in regenerative medicine is limited by the challenge in obtaining sufficient cell numbers while maintaining self-renewal capacity.  Our efforts in developing 3D-printed bioreactors that mimic the bone marrow niche microenvironment have enabled successful expansion of mesenchymal stem cells by recapitulating the physiological surface shear stresses experienced by the cells.  This presentation will cover the diverse range of materials and processes developed in our laboratory and their application to relevant, emerging problems in tissue engineering.

Add to Calendar ▼2018-03-26 00:00:002018-03-27 00:00:00Europe/London3D-Bioprinting and Tissue