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SELECTBIO Conferences EV-based Diagnostics, Delivery & Therapeutics

My Mahoney's Biography

My Mahoney, Professor and Vice Chair, Thomas Jefferson University

Currently a Professor and Vice Chair of Equal Opportunity and Workforce Diversity, Department of Dermatology & Cutaneous Biology at Thomas Jefferson University.

Joint appointment in Biochemistry & Molecular Biology and a member of the Sidney Kimmel Cancer Center. Permanent reviewer for the Arthritis and Musculoskeletal and Skin Diseases (AMS) Special Grants Review Committee for the NIH. At TJU, a founding member of the Reprogramming to Revive Regeneration and Stimulate Tissue and Organ Repair (R?STORE) group whose goal is to assess the cellular networks that stimulate tissue and organ regeneration for functional repair. Also belong to the Squamous Cell Carcinoma Tumor Ecology and Microenvironment (STEM) Research Group whose goal is to address how interactions in the tumor microenvironment (TME) be used to prevent disease progression and treatment resistance in SCC.

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miRNA- and Cytokine-Associated Extracellular Vesicles Mediate Squamous Cell Carcinomas

Tuesday, 18 February 2020 at 14:00

Add to Calendar ▼2020-02-18 14:00:002020-02-18 15:00:00Europe/LondonmiRNA- and Cytokine-Associated Extracellular Vesicles Mediate Squamous Cell CarcinomasEV-based Diagnostics, Delivery and Therapeutics in Coronado Island, CaliforniaCoronado Island,

Extracellular vesicles (EVs) serve as intercellular messengers carrying lipids, proteins, and genetic material that have been shown to play a significant role in many pathological conditions, including cancer. We recently demonstrated that the cadherin desmoglein 2 (Dsg2), a stem cell marker upregulated in many cancers, modulates EV biogenesis in squamous cell carcinomas (SCCs). Here, we show that this process occurs through the endocytic pathway and requires membrane association through protein palmitoylation. In SCC xenograft models, tumor size correlated with EV release and co-treatment with EVs increased xenograft size. To assess the molecular messengers contributing to the pathogenicity of Dsg2-mediated EVs, a cytokine antibody array was employed to show that Dsg2 stimulates release of multiple cytokines known to promote angiogenesis and inflammation, both of which enhance tumor growth. Profiling by RNAseq showed dramatic down-regulation of miRNAs that target those cytokines. These results suggest that intercellular communication through cell-cell adhesion, cytokine release, and secretion of extracellular vesicles are coordinated, critical for tumor growth and development.

Add to Calendar ▼2020-02-17 00:00:002020-02-18 00:00:00Europe/LondonEV-based Diagnostics, Delivery and TherapeuticsEV-based Diagnostics, Delivery and Therapeutics in Coronado Island, CaliforniaCoronado Island,