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SELECTBIO Conferences Circulating Biomarkers World Congress 2019

Yves A. DeClerck's Biography



Yves A. DeClerck, Professor of Pediatrics and Biochemistry & Molecular Medicine, Children’s Hospital Los Angeles, University of Southern California

Yves DeClerck, MD, is a Pediatrician-Scientist at Children’s Hospital Los Angeles and USC, and the holder of the Richard Call Family Chair in Pediatric Research Innovation. He is leading a cancer biology research program focused on the Tumor Microenvironment (TME) and its contribution to cancer progression and metastasis. The main objective of the laboratory is to understand fundamental mechanisms of communication between tumor cells and stromal cells in the TME in order to identify targets for therapeutic intervention that can be tested in relevant pre-clinical models. The research program has 3 major directions: (1) Contribution of MSC and cancer-associated fibroblasts (CAF) to neuroblastoma progression; (2) Contribution of exosomes and extracellular vesicles to the education of CAF/MSC and macrophages by tumor cells; and (3) Role of plasminogen activator inhibitor-1 (PAI-1) in cancer progression.

Dr. DeClerck is an Associate Director and Program Co-leader at the USC Norris Comprehensive Cancer Center, a Senior Editor for Molecular Cancer Research and a member of numerous scientific review groups at the NIH, Cancer Prevention and Research Institute of Texas, and European Research Commission.

Yves A. DeClerck Image

Tumor-derived Exosomes Contribute to a Pro-inflammatory Tumor Microenvironment through the Stimulation of Chemokines and Cytokines in Mesenchymal Stromal Cells and Macrophages

Wednesday, 27 March 2019 at 14:00

Add to Calendar ▼2019-03-27 14:00:002019-03-27 15:00:00Europe/LondonTumor-derived Exosomes Contribute to a Pro-inflammatory Tumor Microenvironment through the Stimulation of Chemokines and Cytokines in Mesenchymal Stromal Cells and MacrophagesCirculating Biomarkers World Congress 2019 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com

Exosomes are members of a large family of extracellular vesicles involved in cell-cell communication that play important regulatory functions in physiological and pathological conditions. Using neuroblastoma (NB), the second most common solid tumor in children and a cancer that is highly metastatic to the bone marrow and the liver as a model, we show that NB-derived exosomes contribute to the stimulation of several protumorigenic cytokines and chemokines (IL-6, IL-8, MCP-1, VEGF) by mesenchymal stromal cells (MSC) and macrophages via ERK1/2 activation.  In vivo NB-derived exosomes are also preferentially captured by macrophages at the site of metastasis (bone marrow and liver).  Altogether these cytokines promotes the proliferation of tumor cells, their resistance to chemotherapy and immune escape via STAT3 and ERK1/2 activation.


Add to Calendar ▼2019-03-27 00:00:002019-03-29 00:00:00Europe/LondonCirculating Biomarkers World Congress 2019Circulating Biomarkers World Congress 2019 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com