Corinna Keup,
Researcher,
Universitätsklinikum Essen, Klinik für Frauenheilkunde und Geburtshilfe
Corinna Keup studied biochemistry and molecular biomedicine in Duesseldorf and Muenster, Germany. In her master thesis, performed at QIAGEN GmbH, she focused on preanalytical challenges regarding the analysis of extracellular vesicles. Currently Corinna Keup is working as a PhD student in the lab of Prof. Sabine Kasimir-Bauer at the Department of Gynecology and Obstetrics, University Hospital of Essen, Germany. Her research focuses on the potential of liquid biopsies for therapy stratification of metastatic breast cancer patients. In cooperation with QIAGEN GmbH, Hilden, she established a new multimarker qPCR panel for the comparison of mRNA profiles of circulating tumor cells and extracellular vesicles. This work was awarded with the travel grant at the 3RD ACTC conference 2017 in Rhodes and was published in Clinical Chemistry (Keup et al. 2018).
mRNA Profiles of Circulating Tumor Cells and Extracellular Vesicles in Matched Samples From Metastatic Breast Cancer Patients
Wednesday, 24 October 2018 at 13:30
Add to Calendar ▼2018-10-24 13:30:002018-10-24 14:30:00Europe/LondonmRNA Profiles of Circulating Tumor Cells and Extracellular Vesicles in Matched Samples From Metastatic Breast Cancer PatientsExosomes and Liquid Biopsies Europe 2018 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
The analysis of RNA enclosed in circulating tumor cells (CTCs) or extracellular vesicles (EVs) may be sensitive enough to detect disease progression earlier than contemporary visual staging methods. A prediction of the ideal therapy strategy via characterization of CTCs or EVs would be even more beneficial. We, for the first time, compared RNA profiles of CTCs and EVs in metastatic breast cancer (MBC) patients to get insights about their feasibility for therapy stratification.
CTCs were isolated by positive immunomagnetic selection targeting EpCAM, EGFR and HER2 with the AdnaTest EMT-2/StemCell SelectTM, QIAGEN GmbH and EVs were isolated by affinity-based binding to a spin column with the exoRNeasy Serum/Plasma protocol, QIAGEN GmbH. mRNA was purified, reverse transcribed and pre-amplified cDNA was analysed for 18 genes by multimarker qPCR assays (AdnaTest TNBC Panel prototype, QIAGEN GmbH).
Add to Calendar ▼2018-10-24 00:00:002018-10-26 00:00:00Europe/LondonExosomes and Liquid Biopsies Europe 2018Exosomes and Liquid Biopsies Europe 2018 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2018-10-24 13:30:002018-10-24 14:30:00Europe/LondonmRNA Profiles of Circulating Tumor Cells and Extracellular Vesicles in Matched Samples From Metastatic Breast Cancer PatientsExosomes and Liquid Biopsies Europe 2018 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
