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SELECTBIO Conferences BioEngineering Summit 2019

E. Brandon Strong's Biography

E. Brandon Strong, NSF Graduate Research Fellow, California Polytechnic State University, San Luis Obispo

Brandon Strong recently graduated with his bachelor’s in biology in 2018 and is currently a National Science Foundation Graduate Research Fellow in the Martinez Lab at California Polytechnic State University, San Luis Obispo. He is currently enrolled in two master’s programs, a master’s in biology at Cal Poly, and a master’s in computer science at the University of Pennsylvania. His research over the last four years has focused on the development of point-of-care diagnostic devices on both 3D-printed and paper-based microfluidic platforms. This work has resulted in 9 peer-reviewed publications, a handful of patent applications, 15 co-authored research grants/awards totaling 600,000 USD, and 48 conference presentations across the United States and around the world. Following the completion of his master’s degrees, he intends to pursue a combined MD/PhD program.

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Fabrication of Microfluidic Devices with Integrated Electronic Components via Dual Extrusion-Based 3D Printing

Monday, 1 April 2019 at 15:00

Add to Calendar ▼2019-04-01 16:30:002019-04-01 17:30:00Europe/LondonNext-Generation MicroPADs: Merging 3D Printing with Microfluidic Paper-Based Analytical Devices (MicroPADs)

Current microfabrication techniques typically require complex, labor-intensive processes. An alternative method of economical and rapid prototyping is extrusion-based 3D printing. While 3D printing has more recently been applied to the field of microfluidics, channel resolution is poor.  Furthermore, since the current generation of microfluidics devices require the integration of electronic components, we utilized dual extrusion-based 3D printing, thereby allowing for the prototyping of multi-material microfluidic devices with integrated electronics. Devices were designed in SolidWorks (modeling software), exported to BCN3D Cura (slicing program), and printed via BCN3D Sigma (dual-extrusion 3D printer). For devices with electronic components, conductive polylactic-acid (PLA) was inlaid within a non-conductive PLA framework to create an internal circuitry.

Functional open-faced microfluidics channels as small as 50 µm in width were produced. However, 100 µm width channels were more highly reproducible. Fully enclosed horizontal (200-500 µm) and vertical (750-1000 µm) channels were also fabricated. Hybrid devices contained both vertical and horizontal channels to create 3D fluidic arrays. Multi-layered electronic devices with multi-electrode microfluidic wells were created and allowed for simple electroanalysis. 3D printed electronic circuits were also used to thermally actuate paraffin valves in microfluidics channels, which may allow for the automation of multi-step reactions.

Next-Generation MicroPADs: Merging 3D Printing with Microfluidic Paper-Based Analytical Devices (MicroPADs)

Monday, 1 April 2019 at 16:30

Add to Calendar ▼2019-04-01 16:30:002019-04-01 17:30:00Europe/LondonNext-Generation MicroPADs: Merging 3D Printing with Microfluidic Paper-Based Analytical Devices (MicroPADs)

Microfluidic Paper-Based Analytical Devices (MicroPADs) have emerged as useful diagnostic tools. They possess many key characteristics, including portability, cost-effectiveness, ease of use, low sample volume requirements, and ability to operate without supporting equipment. Researchers have modified microPADs in a myriad of ways to increase functionality, however, the use of 3D printing on microPADs has yet to be explored. The purpose of this project was to use 3D printing to expand microPAD functionality and combat current limitations. MicroPADs were fabricated on chromatography paper via wax printing and affixed to the bedplate of a BCN3D Sigma (dual-extrusion 3D printer). Polylactic acid (PLA) and conductive PLA structures were fabricated on microPADs via 3D printing. 3D fluid reservoirs were fabricated from PLA and allowed for larger sample volumes and further wicking distances on microPADs. Electrodes were fabricated from conductive PLA and allowed for simple electroanalysis on paper. Hybrid devices with both PLA channels (100 µm) and paper channels were also created. PLA-backed hemi- and fully-enclosed paper channels were fabricated, which may allow for increased robustness and reduced contamination of biochemical assays on microPADs, as well as the ability to run devices in direct contact with surfaces (i.e., not held in suspension).

Add to Calendar ▼2019-04-01 00:00:002019-04-02 00:00:00Europe/LondonBioEngineering Summit