Shopping Cart (0)
My Account

Shopping Cart
SELECTBIO Conferences Biofabrication & Biomanufacturing Europe 2019

Nathaniel Huebsch's Biography



Nathaniel Huebsch, Assistant Professor of Biomedical Engineering, Washington University Saint Louis

Nate Huebsch completed his BS in Bioengineering in 2003 from the University of California, Berkeley. He completed his PhD training through the Harvard-MIT Division of Health Sciences and Technology, and then worked as a postdoctoral fellow and research scientist at the Gladstone Institute of Cardiovascular Disease where he held fellowships from the NIH (NRSA) and the California Institute of Regenerative Medicine. He served as the lead scientist on the Microphysiological Systems team in the laboratory of Kevin Healy at the University of California, Berkeley before joining the department of Biomedical Engineering at Washington University in Saint Louis in 2018. His research focus is on understanding how mechanical loading and passive matrix mechanical properties contribute to pathogenesis of inherited cardiomyopathies and stem cell differentiation.

Nathaniel Huebsch Image

Metabolic Cues Enhance Maturation of Human iPSC-derived Cardiomyocytes in a Cardiac Microphysiological System

Friday, 21 June 2019 at 15:00

Add to Calendar ▼2019-06-21 15:00:002019-06-21 16:00:00Europe/LondonMetabolic Cues Enhance Maturation of Human iPSC-derived Cardiomyocytes in a Cardiac Microphysiological SystemBiofabrication and Biomanufacturing Europe 2019 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com

Human Induced Pluripotent Stem Cells (iPSC) have great potential for enhancing drug development and basic understanding of disease processes. However, the immature nature of iPSC-derived tissue cells limits our ability to use them to predict the response of adult human tissues. We used Design of Experiments enhanced screening to identify a fatty-acid based medium that enhanced the electrophysiological (action potential) maturation of iPSC-cardiomyocytes in a Microphysiological System. In silico modeling combined with pharmacology suggested that changes in calcium handling underlie the action potential maturation. Ongoing studies are focused on instrumenting iPSC-cardiac micro-tissues to enable continuous non-optical electrophysiology analysis with micro-electrode arrays.


Add to Calendar ▼2019-06-20 00:00:002019-06-21 00:00:00Europe/LondonBiofabrication and Biomanufacturing Europe 2019Biofabrication and Biomanufacturing Europe 2019 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com