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SELECTBIO Conferences 3D-Culture, Organoids & Tox Screening Europe 2019

David Pamies's Biography

David Pamies, Researcher, University of Lausanne

David Pamies is a Researcher at the Department of Physiology on the Lausanne University. He got his master in Bioengineering and Ph.D. in the Miguel Hernandez University. The focus of his PhD research was to elucidate the role of neuropathy target esterase (NTE) in the differentiation processes, using mouse embryonic stem cells in order to determine their role as a possible target in mammalian embryonic development toxicity and human NT2 cells to identify the role of NTE in the processes of differentiation to form the neuroectoderm. Thus, his research was mainly focused on the use of in vitro systems to study neurodevelopmental processes. He also was working one year in the IHCP (European Commission). During his trainee period at the European Commission Joint Research Center (JRC), He was working in new 3D models to assess developmental neurotoxicity (DNT). Afterward, he joined the Center for Alternatives to Animal Testing in January 2013, where he was working for 5 years, first as a postdoc and after as a research associated on developing and application of an iPSC-derived 3D human brain microphysiological system to study DNT, encephalitis, virus infection, Parkinson disease (PD) between others. Now, he is working on the use of new in vitro technologies to quantify adverse outcome pathways (AOPS) to help regulatory decision-making.

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BrainSpheres to Study Developmental Neurotoxicity

Thursday, 13 June 2019 at 15:15

Add to Calendar ▼2019-06-13 15:15:002019-06-13 16:15:00Europe/LondonBrainSpheres to Study Developmental Neurotoxicity3D-Culture, Organoids and Tox Screening Europe 2019 in Rotterdam, The NetherlandsRotterdam, The

Developmental neurotoxicity is of high concern due to different reasons: 1) no routine testing for DNT is carried out in the U.S., in the EU, or elsewhere, as DNT testing is not required by law unless triggered by neurotoxic or endocrine effects in adult rodents, 2) DNT guidelines are expensive and time-consuming, 3) human brain complexity may not be completely tested by animal testing, and 4) brain defects can be difficult to detect. Experts in the field have suggested an in vitro testing battery to cover brain development key events (such as neural stem cell proliferation and differentiation, migration, neurite outgrowth, synaptogenesis, network formation, myelination, and apoptosis). Also, the use of more human-relevant models, using 3D organotypic iPSC derived systems, have been suggested as an alternative to classical in vitro models. Here we present a 3D brain human-derived iPSC model to study developmental neurotoxicity and different applications of the model.

Add to Calendar ▼2019-06-13 00:00:002019-06-14 00:00:00Europe/London3D-Culture, Organoids and Tox Screening Europe 20193D-Culture, Organoids and Tox Screening Europe 2019 in Rotterdam, The NetherlandsRotterdam, The