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SELECTBIO Conferences Microfluidics & Flow Chemistry Europe 2020

Shinichiro Fuse's Biography



Shinichiro Fuse, Professor, Nagoya University

Shinichiro Fuse has been a professor of chemistry at Nagoya University since 2019. He earned his B.S. degree in 2000 and his Ph.D. in 2005 from Tokyo Institute of Technology under the supervision of Prof. Takashi Takahashi. He was a researcher at ChemGenesis Incorporated between 2005 and 2006, and a postdoctoral fellow from 2006 to 2008 at Harvard University in the group of Prof. Daniel E. Kahne. In 2008, he joined the faculty at the Tokyo Institute of Technology as an assistant professor. He then moved to the Chemical Resources Laboratory at the same university as an associate professor in 2015. His research is aimed toward the development of efficient synthetic processes based on a deep understanding of organic chemistry using flow synthesis, automated synthesis, theoretical calculations, and machine-learning technologies.

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Micro-Flow Synthesis of Amino Acid N-Carboxy Anhydrides and Their Derivatization via pH Flash Switching and Rapid Dual Activation

Thursday, 10 September 2020 at 16:45

Add to Calendar ▼2020-09-10 16:45:002020-09-10 17:45:00Europe/LondonMicro-Flow Synthesis of Amino Acid N-Carboxy Anhydrides and Their Derivatization via pH Flash Switching and Rapid Dual ActivationMicrofluidics and Flow Chemistry Europe 2020 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com

Amino Acid N-Carboxy Anhydrides (NCAs) are important as monomers in polypeptide synthesis. The most conventional synthetic approach for NCAs uses strong acidic conditions. Therefore, NCAs containing acid-labile functional groups cannot be prepared. On the other hand, NCAs canbe rapidly generated under basic conditions, however, they rapidly occur overreactions under the basic conditions. We developed and used pH flash switching technology in a micro-flow reactor. Acid-labile NCAs were successfully prepared by our developed approach. We also demonstrated derivatization of labile NCAs using rapid dual activation of both NCAs and electrophiles in a micro-flow reactor.


Add to Calendar ▼2020-09-10 00:00:002020-09-11 00:00:00Europe/LondonMicrofluidics and Flow Chemistry Europe 2020Microfluidics and Flow Chemistry Europe 2020 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com