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SELECTBIO Conferences The Space Summit 2019

Sonja Schrepfer's Biography

Sonja Schrepfer, Professor of Surgery, University of California-San Francisco

Dr. Schrepfer has been working in transplant immunology since the mid-1990s. In addition to her research background, she was trained in cardiac surgery and heart/lung transplantation. She had her first publication on the mouse cardiac model when she was still in medical school. After graduation, she was a resident in the Cardiothoracic Surgery Departments in Munich and Hamburg (Germany) before pursuing a career as a full-time scientist. She received her PhD in transplant immunology and founded the Transplant and Stem Cell Immunobiology (TSI) Lab at Stanford University in the Department of CT Surgery in 2007, focusing on pluripotent stem cells and their immunobiology for regenerative medicine. In 2009, Dr. Schrepfer was the youngest full Professor in Medicine appointed in Germany, and subsequently, was awarded the prestigious DFG-Heisenberg professorship. Her work is funded by the Leopoldina Academy of Science, Leducq Fondation, NASA, CIRM, NIH and CASIS to understand the immunobiology of pluripotent stem cells and immune activation/senescence. Dr. Schrepfer is currently Professor in the Department of Surgery at UCSF and made significant contributions to the field of regenerative medicine, improving our understanding of associated immunological barriers even in autologous recipients.

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Immunological Senescence in Space Affects Stem Cell Behavior and Function

Monday, 14 October 2019 at 13:30

Add to Calendar ▼2019-10-14 13:30:002019-10-14 14:30:00Europe/LondonImmunological Senescence in Space Affects Stem Cell Behavior and FunctionThe Space Summit 2019 in Coronado Island, CaliforniaCoronado Island,

Aging is associated with dysregulation of the immune response, which is also termed “immunosenescence.” Each part of the immune system is influenced to some extent by the aging process. However, adaptive immunity seems more extensively affected, and it is especially the T cells that are altered. In fact, the number and proportion of late-differentiated T cells (so called TEMRA cells), is higher in the elderly than in the young and their accumulation may contribute to the enhanced systemic pro-inflammatory milieu commonly seen in elderly individuals. We do not know exactly what causes these observed changes, but an understanding of the possible causes is now beginning to emerge. Spaceflight causes a suite of negative health effects that may be comparable to immunosenescence, which seems to be a key regulator of the regenerative capacity of tissue- and organ-specific stem cells. Specifically, studies examining the effects of bone healing (by mesenchymal stromal cells; MSCs) and vascular regeneration (by endothelial progenitor cells; EPCs) were performed using tissue mimics on chip to represent “semi-3D” architectures.

Add to Calendar ▼2019-10-14 00:00:002019-10-15 00:00:00Europe/LondonThe Space Summit 2019The Space Summit 2019 in Coronado Island, CaliforniaCoronado Island,