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SELECTBIO Conferences Bioengineering for Building Microphysiological Systems 2022

Mandy Esch's Biography

Mandy Esch, Project Leader, National Institute of Standards and Technology (NIST)

Mandy B. Esch is a project leader in the Microsystems and Nanotechnology Division. She received an Diploma (equivalent to the American M.S. degree) in Biology and a Dr. rer. nat. (equivalent to the American Ph.D. degree) in Biotechnology from the Julius Maximilians University in Würzburg, Germany. During her PhD research she developed paper-based microfluidics and biosensors for the detection of pathogens such as Cryptosporidium parvum. In 2001, Dr. Esch joined the Cornell Nanoscale Science and Technology Facility as life sciences liaison. In 2007, she joined the Department of Biomedical Engineering at Cornell University as a Postdoctoral Research Associate. While there, she developed patents for cell culture on a porous 3D surface and for a multi-organ microphysiological system (MPS). Together with her colleagues of a team that designed multi-organ fluidic cell culture systems, she received the 2015 Lush Science Prize. From 2015 to 2016 Dr. Esch spent a year as Assistant Professor at Syracuse University (Department of Biomedical and Chemical Engineering). She taught nanobiotechnology and built a laboratory for tissues-on-chips research. In August 2016 Dr. Esch moved to NIST, where she is focusing on integrating sensors with tissues-on-a-chip and multi-organ microphysiological systems.

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Development of Pumpless Single-Organ and Multi-Organ Microphysiological Devices

Monday, 24 October 2022 at 16:30

Add to Calendar ▼2022-10-24 16:30:002022-10-24 17:30:00Europe/LondonDevelopment of Pumpless Single-Organ and Multi-Organ Microphysiological DevicesBioengineering for Building Microphysiological Systems 2022 in Rotterdam, The NetherlandsRotterdam, The

We developed several pumpless microphysiological cell culture systems that can be used to co-culture interconnected human tissues with near-physiological amounts of recirculating blood surrogate (cell culture medium). Our GI-tract – liver system can simulate the oral uptake and first pass metabolism of drugs, and our two-organ and four-organ systems can be used to detect primary and secondary drug toxicities. Short channel connections and pumpless operation using gravity enabled us to reduce the amount of liquid needed to operate the systems. We demonstrate the systems with tissues scaled at 1/73,000 and cultured under drug exposure for 24 h. Our approach allows us to reduce the dilution of recirculating drug metabolites that cause acute toxicity. Better predictions of drug toxicity and efficacy with in vitro systems are needed, since clinical trials with humans often do not reproduce the results seen with animal models.

Add to Calendar ▼2022-10-24 00:00:002022-10-25 00:00:00Europe/LondonBioengineering for Building Microphysiological Systems 2022Bioengineering for Building Microphysiological Systems 2022 in Rotterdam, The NetherlandsRotterdam, The