Generation of Universal Donor Cell and its ApplicationTuesday, 12 November 2019 at 13:50  Add to Calendar ▼2019-11-12 13:50:002019-11-12 14:50:00Europe/LondonGeneration of Universal Donor Cell and its ApplicationCell and Gene Therapy Asia 2019 in Kobe, JapanKobe, JapanSELECTBIOenquiries@selectbiosciences.comIt is expected that “Cell” would be the modality which can cure patients suffered from diseases currently with no effective therapeutic option. One of the challenges for the industrialization and promotion of cell therapy is immune rejection. Universal cells, Inc. have developed HLA Knock-out type Universal Donor Cells (UDCs) from pluripotent stem cells, which express non-polymorphic HLA-E molecule for protection from NK cell-mediated “missing-self” cell lysis and a suicide gene for safety by using recombinant Adeno Associated Virus-mediated accurate and safe gene editing method. UDCs can be differentiated to any types of cells and then transplanted in patients without HLA-matching and potentially immunosuppressive treatment. UDCs also have advantages including higher consistency of cell therapy products (no donor-derived variability), reduced Cost of Goods (scalable manufacturing from one cell source), higher safety (no or reduced immunosuppression, more thorough analysis and quality management) and higher efficacy (better clinical trial design). Details of our approach for Universal Donor Cell and its application will be presented. |
Add to Calendar ▼2019-11-11 00:00:002019-11-12 00:00:00Europe/LondonCell and Gene Therapy Asia 2019Cell and Gene Therapy Asia 2019 in Kobe, JapanKobe, JapanSELECTBIOenquiries@selectbiosciences.com
