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SELECTBIO Conferences Immuno-Oncology Europe 2019

Nathaniel Wang's Biography



Nathaniel Wang, Head of R&D, Synthetic Genomics

Dr. Wang is the Head of R&D for RNA Medicines at Synthetic Genomics, Inc. Dr. Wang received his PhD from The Scripps Research Institute and is an experienced scientist in cellular immunology and molecular genetics. Dr. Wang leads Discovery, Preclinical, and Process Development groups for a portfolio of immuno-oncology and infectious disease programs focused on RNA technologies. He has extensive experience relating to the molecular determinants of immunological memory formation following vaccination as well as design of immuno-oncology fixed regime therapies.

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Development of Synthetic Self-Replicating RNA Platforms For Oncology Vaccines and Therapeutics

Monday, 28 October 2019 at 17:00

Add to Calendar ▼2019-10-28 17:00:002019-10-28 18:00:00Europe/LondonDevelopment of Synthetic Self-Replicating RNA Platforms For Oncology Vaccines and TherapeuticsImmuno-Oncology Europe 2019 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com

RNA as a vaccine and therapeutic modality has become a focus of significant interest.  SGI has engineered a novel, self-replicating RNA that overcomes existing limitations and has shown improved immunogenicity and versatility for use in immuno-oncology therapeutics. Vaccination with an engineered self-replicating RNA encoding a neoantigen leads to polyfunctional neoantigen-specific CD4+ and CD8+ T cell responses that inhibited tumor growth, with additional synergy observed with the administration of anti-PD-1 antibody. Self-replicating RNAs are also capable of generating T cell responses of sufficient magnitudes and quality to provide survival advantages when administered as a monotherapy. Combined with the capability of self-replicating RNAs to express biologics, this technology represents a future avenue for multidimensional therapies.


Add to Calendar ▼2019-10-28 00:00:002019-10-29 00:00:00Europe/LondonImmuno-Oncology Europe 2019Immuno-Oncology Europe 2019 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com