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SELECTBIO Conferences Organ-on-a-Chip & Tissue-on-a-Chip Europe 2019

Michael Bscheider's Biography

Michael Bscheider, Group Leader, Roche Pharma Research and Early Development

Michael Bscheider is a group leader at Roche pRED’s preclinical Investigative Safety department in Basel. In 2010, he graduated from LMU Munich Medical School with his thesis on innate immune recognition of viruses and fungi. After a postdoc at the TU Munich on the interplay of immunology and gut epithelium repair during bone marrow transplantation, he worked at Stanford to investigate the development and function of immune cells and lymphoid structures in a tissue-specific context. He now heads labs that aim to leverage in-vitro systems for early safety assessments in immunomodulating drug development.

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Immunocompetent Gut-on-a-Chip as a Model of Tissue Inflammation

Tuesday, 18 June 2019 at 17:15

Add to Calendar ▼2019-06-18 17:15:002019-06-18 18:15:00Europe/LondonImmunocompetent Gut-on-a-Chip as a Model of Tissue InflammationOrgan-on-a-Chip and Tissue-on-a-Chip Europe 2019 in Rotterdam, The NetherlandsRotterdam, The

Owing to its complex and multifactorial nature, inflammatory bowel disease (IBD) remains poorly understood, which, in turn, renders the development of effective IBD therapies a major challenge. The poor translatability of IBD therapeutics from mice to humans may be attributed in large part to the fundamental immunological differences between the two species. Advanced three-dimensional (3D) culture models and microphysiological systems are emerging as superior alternatives to animals in capturing human-specific physiology and disease. We have created an immune-competent gut-on-a-chip model comprising a tight intestinal epithelial barrier, extracellular matrix, resident and circulating immune cells. Beyond a mere co-culture, the system recapitulates the crucial multidirectional interactions between matrix, parenchymal and immune cells that generate an inflammatory milieu and ultimately result in epithelial damage in the context of IBD. The physiological completeness of the model may help afford fundamental insight into the mechanisms that drive chronic inflammation in the gut and other organs, ultimately supporting drug discovery.

Add to Calendar ▼2019-06-18 00:00:002019-06-19 00:00:00Europe/LondonOrgan-on-a-Chip and Tissue-on-a-Chip Europe 2019Organ-on-a-Chip and Tissue-on-a-Chip Europe 2019 in Rotterdam, The NetherlandsRotterdam, The