| Conferences \ Extracellular Vesicles 2022: Biology, Disease & Medicine \ Agenda \ Xiaoli Yu |
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Glioblastoma Extracellular Vesicle Specific Peptides Inhibit EV-induced Neuronal CytotoxicityWednesday, 14 September 2022 at 14:00  Add to Calendar ▼2022-09-14 14:00:002022-09-14 15:00:00Europe/LondonGlioblastoma Extracellular Vesicle Specific Peptides Inhibit EV-induced Neuronal CytotoxicityExtracellular Vesicles 2022: Biology, Disease and Medicine in SeattleSeattleSELECTBIOenquiries@selectbiosciences.comGlioblastoma (GBM) is the most aggressive and lethal form of brain tumors. Tumor cells release extracellular vesicles (EVs) which have been shown to play a critical role in cellular communication in the tumor micro-environment. We discovered that GBM plasma EVs were smaller in size, had no relationship between size and concentration, but showed highly significant correlation between EV concentration and plasma protein concentration. Importantly, GBM EVs purified from both plasma and tumor cell line produced IgG-mediated, complement dependent cytotoxicity in neurons. We identified high affinity phage peptides for GBM EVs by screening phage-displayed random peptide libraries. Significantly, we showed that GBM EV peptides inhibit EV-induced complement-dependent cytotoxicity in neurons in dose- and time-dependent manner. Phage peptide technologies can be used for isolation and characterization of EVs derived from brain tumors. EV specific peptides can be explored for biomarkers and mechanisms of brain tumor EV-induced neuronal death. |
Add to Calendar ▼2022-09-13 00:00:002022-09-14 00:00:00Europe/LondonExtracellular Vesicles 2022: Biology, Disease and MedicineExtracellular Vesicles 2022: Biology, Disease and Medicine in SeattleSeattleSELECTBIOenquiries@selectbiosciences.com
